Abstract Sepsis, a life-threatening organ dysfunction induced by severe infection and uncontrolled host immune response, threatens the health of people all over world. Herein, type nanoparticle formulation with simple components is synthesized encapsulating monophosphoryl lipid A (MPLA), TLR4 agonist, poly(lactic-co-glycolic acid) (PLGA) nanoparticle. The obtained nanoparticles (MPLA@PLGA) coul...