Brucellae are gram-negative, facultative intracellular bacteria which are one of the most common causes of abortion in animals. In addition, they are the source of a severe zoonosis. In this trial, we evaluated the effect of oral inoculation of Brucella abortus RB51 in mice against a challenge infection with B. abortus 2308. First, we showed that a gastric acid neutralization prior to the oral ...

oregano (origanum vulgare l.), a native plant from iran, belongs to lamiaceae family. this species is traditionally utilized as sedative, diuretic, sweater and antiseptic, it is also used to treat of gastrointestinal diseases and constipation. origanum species are widely used in spice industry. in this study, the essential oil of the aerial parts of a subspecies from this plant namely origanum ...

BACKGROUND Ficus lutea crude acetone leaf extracts were previously shown to stimulate glucose uptake and insulin secretion of established cells and, inhibit α-amylase and α-glucosidase activities. METHODS For this study, F. lutea acetone extracts were subjected to solvent-solvent fractionation to yield fractions with differing polarities (hexane, chloroform, dichloromethane, ethyl acetate, n-...

The hydrothermal reactions of [A-α-PW9O34](9-) with CuCl2·2H2O in the presence of ethanediamine (en) and acetate afforded a novel poly(polyoxotungstate) containing different lacunary fragments: monolacunary {α-PW11O39}, dilacunary {α-PW10O37}, trilacunary {B-α-PW9O34}, etc. In addition, a cockhorse-like nona-copper {Cu9} slab is incorporated. Magnetic investigation indicates overall antiferroma...

The functional determinants of the insulinotropic action of α-d-glucose pentaacetate were investigated in rat pancreatic islets. The ester mimicked the effect of nutrient secretagogues by recruiting individual B cells into an active secretory state, stimulating proinsulin biosynthesis, inhibiting86Rb outflow, and augmenting45Ca efflux from prelabeled islets. The secretory response to the ester ...

BACKGROUND We have previously reported that aerial parts of Tylophora hirsuta have antispasmodic profile. The current work is an attempt for isolation of pharmacologically active compound(s) that contribute for its antispasmodic activity. METHODS Preliminary phytochemical screening for crude methanol extract of Tylophora hirsuta (Th.Cr) is performed. Brine shrimp cytotoxicity of crude methano...

Effects of α-, β-, γ- and δ-tocopherols on the proliferation and invasion of AH109A hepatoma cells and their modes of action were investigated. Four tocopherols inhibited the invasion as well as the proliferation of AH109A cells. Their inhibitory effects were more prominent on the invasion than on the proliferation. At 1 µM, α-tocopherol showed most potent anti-invasive activity without any inf...

Diabetes mellitus is a metabolic disorder of glucose metabolism which correlates with postprandial hyperglycemia and oxidative stress. Control of blood glucose level is imperative in the management of diabetes. The present study tested the hypothesis that Costus afer, an antihyperglycemic medicinal plant, possesses inhibitory activity against carbohydrate hydrolyzing enzymes. Hexane, ethyl acet...

The volatile constituents from roots of Valeriana officinalis L. were investigated using GC and GC/MS methods. Valerianae radix samples were obtained from retail pharmacies or cultivated in Estonia. The roots of five V. officinalis samples yielded 0.28–1.16% essential oil in the cut drug, which usually corresponded (four samples) to the European Pharmacopeia standard (0.3%). The basic oil compo...