The GTPase dynamin polymerizes into a helical coat that constricts membrane necks of endocytic pits to promote their fission. However, the dynamin mechanism is still debated because constriction is necessary but not sufficient for fission. Here, we show that fission occurs at the interface between the dynamin coat and the uncoated membrane. At this location, the considerable change in membrane ...

Drug-membrane interactions are well known but poorly understood. Here we describe dual measurements of membrane thickness change and membrane area change due to the binding of the amphipathic drug curcumin. The combined results allowed us to analyze the binding states of a drug to lipid bilayers, one on the water-membrane interface and another in the hydrocarbon region of the bilayer. The trans...

Interfaces are ubiquitous in nature and absolutely key for life as illustrated by such complex interfaces as the cell membrane and the endothelial and epithelial linings of tissues. The mechanical properties of these interfaces play an important role in their biological functions. In this highlight, we describe our recent work (Pocivavsek et al., Science, 2008, 320, 912) using geometry as a too...

In vivo aspiration experiments on human livers are analyzed and material parameters for a non-linear-viscoelastic constitutive model are determined. A novel procedure is applied for the inverse analysis that accounts for the initial tissue deformation in the experiment and for the non-homogeneity of liver tissue. A numerical model is used consisting of a surface layer (capsule) and an underlyin...

Although the auger-like 'swimming' motility of the African trypanosome was described upon its discovery over one hundred years ago, the precise biomechan-ical and biophysical properties of trypanosome flagellar motion has not been elucidated. In this study, we describe five different modes of flagellar beat/wave patterns in African trypanosomes by microscopically examining the flagellar movemen...

in this research a numerical analysis using plaxis program has been carried out to investigate the behavior of buried concrete box culverts different parameters including load types, loading locations, culvert dimensions, underlying soil specifications, and the coefficient of earth pressure- at- rest. for modeling purpose, patch loading of rtuck or military tank has been substituted to an equiv...

We describe the clinical and pathologic observation of four patients with Porokeratosis of Mibelli. Allof them were women. They had four different forms of disease: Plaque type, functate form, Linear form and superficial disseminated form. In histologic features we observed a new change in basement membrane of epidermis in two patients. This change composed of Liquefaction degeneration of basal...

Examples of fluid motion driven by immersed flexible structures abound in nature. In many biological settings, for instance a beating heart, an active material generates a timedependent internal forcing on the surrounding fluid. Motivated by such active biological structures, this thesis investigates parametric resonance in fluid-structure systems induced by an internal forcing via periodic mod...

A model different from the traditional WEC, known as flexible wave energy converter (fWEC), is numerically modeled in this paper. The fWEC believed to be more efficient and has a greater range of operation when compared with conventionally rigid WEC. fully coupled fluid–structure interaction (FSI) tool developed for research performed This able accommodate dynamic between membrane structure sur...

The importance of nonlinearities in material constitutive relations has long been appreciated in the continuum mechanics of macroscopic rods. Although the moment (torque) response to bending is almost universally linear for small deflection angles, many rod systems exhibit a high-curvature softening. The signature behavior of these rod systems is a kinking transition in which the bending is loc...