Presence of large numbers of acquired melanocytic nevi is a strong risk factor for malignant melanoma in adults. A series of studies conducted over the past 10 to 15 years have shown that the lighter skin color, propensity to burn rather than to tan in the sun, and frequent episodes of childhood sunburn increase nevus prevalence in childhood and adolescence. Solar ultraviolet radiation exposure...

OBJECTIVE To evaluate with immunohistochemical methods 5 atypical melanocytic conjunctival lesions. METHODS This was a retrospective clinicoimmunopathologic study. Routine histochemical staining was performed with multiparametric immunohistochemical analysis with monoclonal antibodies immunoreacted on paraffin sections to identify the following cell antigens: S-100, MART-1, HMB-45, CD45, CD68...

Introduction: Facial melanocytic nevi whether acquired or congenital may pose an aesthetic problem for many patients, especially women. There are many methods of removal of melanocytic nevi including surgical and non-surgical. However, surgical excision by classical fusiform excision remains the most widely used and one of the best methods taking all perspectives into consideration. Aim: To eva...

proper differentiation between acral malignant melanoma and benign pigmented lesions like melanocytic nevi is of great value. to avoid unnecessary biopsies, dermatoscopy has been introduced as a non-invasive modality and has improved the clinical diagnostic accuracy in recent decades. we aimed to describe dermoscopic patterns of acral pigmented lesions of patients in the clinic of dermatology i...

Nestin, a class VI intermediate filament protein, was originally described as a neural stem cell/progenitor cell marker. Expression of nestin has been reported to be associated with the migration and metastasis of various types of tumor. In the present study, we examined the expression of nestin in malignant melanomas and nevi. Immunohistochemical...

BACKGROUND Natalizumab is a monoclonal antibody directed against α₄ integrin used in the treatment of multiple sclerosis (MS). Four cases of melanomas occurring in patients prescribed natalizumab to treat MS were recently reported. Although some fundamental data suggested that α₄β1 integrin could be linked to the invasiveness of melanoma, none showed any relation with the transformation of mela...

OBJECTIVE To compare dermoscopic features of melanocytic nevi with those of early melanomas that were not excised initially because of their uncharacteristic clinical and dermoscopic appearance. DESIGN Retrospective study of the baseline images of 325 melanocytic skin lesions that were observed by digital dermoscopy and finally excised because of changes over time. SETTING A dermatologic cl...

OBJECTIVE To compare factors associated with halo nevi with nonsegmental vitiligo (NSV) vs NSV alone. DESIGN Prospective observational study in 553 patients with a confirmed diagnosis of NSV attending a vitiligo clinic between January 1, 2006, and July 1, 2010. SETTING Vitiligo Clinic at the Department of Dermatology, University Hospital Center of Bordeaux, Bordeaux, France. PATIENTS The ...

Site-specific histopathology features have been reported for acral, auricular, flexural, and genital melanocytic nevi, however, to the best of our knowledge, site- and sex-specific histology of dysplastic nevi on the lower leg (between knee and ankle) of women (DN-LW) has not been reported. In this retrospective histopathology study, we compared DN-LW (N = 42) with appropriate control groups of...