Liposomes are highly flexible vesicular structures that already found practical application in pharmaceutics and cosmetology in the 1980s. current research on liposomes concentrates on their possible use in medicine and animal reproduction biotechnology, including the use of liposomes as a model of sperm cell membrane and as carriers of unstable or easily soluble compounds, and the determinatio...

Laminarin, a water-soluble polysaccharide is known to induce aggregation and fusion of liposomes. Using laminarin specific lysing enzymes for multi-lamellar liposomes their aggregation was found to be fully reversible, in contrast to small unilamellar liposomes for which irreversible fusion is the main process. Moreover, our results indicate that these processes are probably mediated by the for...

Background: In recent years, nanotechnology with modern advances in the macromolecular design of nano-carriers has proved to be helpful in the development of drugs delivery systems. This research represents a novel co-administration of nano-vehicles, known as liposomes. Liposomes efficiently encapsulate curcumin and bromocriptine (BR) in a polymer structure, which results in enhanced aqueous so...

We describe a method for controllably generating giant balloon-like liposomes through electroformation of densely micro-patterned lipid films. These balloon-like liposomes are still tethered to the substrate through a thin lipid tube. We found that the patterns that were more densely spaced generated the balloon-like liposomes, whereas patterns that were sparsely spaced generated hemi-spherical...

Neutral and negatively charged liposomes containing Adria mycin (ADM) were examined for the efficiency of drug entrap ment, serum stability, in vivo tissue distribution, and tumorinhibitory activity. Entrapment of ADM in negatively charged liposomes containing phosphatidylserine (PS) or cardiolipin (DPG) was 3to 4-fold higher than in neutral phosphatidylcholine (PC) liposomes with or without ch...

One of the major obstacles in the development of ligand-targeted liposomes is poor liposome circulation longevity as a result of antibody-mediated elimination of these highly immunogenic carriers. Because studies from our laboratory suggest that it is not possible to reduce the immunogenicity of ligand-conjugated liposomes by using surface-grafted poly(ethylene glycol) (PEG), we investigated th...

BACKGROUND Liposomal-based gadolinium (Gd) nanoparticles have elicited significant interest for use as blood pool and molecular magnetic resonance imaging (MRI) contrast agents. Previous generations of liposomal MR agents contained gadolinium-chelates either within the interior of liposomes (core-encapsulated gadolinium liposomes) or presented on the surface of liposomes (surface-conjugated gad...

Neutral and negatively charged liposomes containing Adria mycin (ADM) were examined for the efficiency of drug entrap ment, serum stability, in vivo tissue distribution, and tumorinhibitory activity. Entrapment of ADM in negatively charged liposomes containing phosphatidylserine (PS) or cardiolipin (DPG) was 3to 4-fold higher than in neutral phosphatidylcholine (PC) liposomes with or without ch...

Liposomal doxorubicin (Lipo-DOX) has been widely and successfully used in chemotherapy for breast cancer patients. Since our previous studies found that 188Rhenium (188Re)-N,N-bis (2-mercaptoethyl)-N',N'-diethy-lethylenediamine (BMEDA)-labeled pegylated liposomes (188Re-liposomes) have radiotherapeutic potential in a colon cancer model, and little information is available to make a comparison o...

An electrostatic complexation of liposomes, composed of anionic palmitoyloleoyl phosphatidylserine (POPS ) and zwitterionic dioleoylphophatidylcholine (DOPC), with bilayer vesicles composed of cationic poly(L-lysine)-b-poly(L-leucine) block copolypeptides has been investigated. The complexation was characterized by several physicochemical methods with the following main conclusions: (a) all add...