Liver plays a key role in glucose metabolism and homeostasis, and impaired hepatic glucose metabolism contributes to the development of type 2 diabetes. However, the precise gene expression profile of diabetic liver and its association with diabetes and related diseases are yet to be further elucidated. In this study, we detected the gene expression profile by high-throughput sequencing in 9-we...

The aim of this study was to investigate the possible effects maternal administration lead acetate on morphological structure liver; AST, ALT, ALP and GGT levels glycogen content hepatocytes male offspring wistar rats. Female rats were exposed 0.2% in drinking water performed their (7 groups). To evaluate liver enzymes, blood samples taken from after anesthesia. After dissection, its hepatocyte...

The intracellnlar distribution of glutamine synthetase (L-glutamate : ammonia ligase (ADP), EC 6.3.1.2 ) in normal and regenerating rat livers has been studied. The distribution of the enzyme activity in liver in these two situations is similar. The highest enzyme activity occurred in the microsome fraction, which comprised about one half of the activity in liver. Although most of the enzyme ac...

Objective(s): Alteration in drug metabolism is very likely in diabetes mellitus. This study assessed changes in CYP2C19 enzymatic activity in the liver using omeprazole as a probe in the animal model of type II diabetes (T2DM) before and after treatment with metformin and cinnamon.Materials and Methods: Twenty-eight male Wistar rats were...

Catecholamines induced an increase in the activity of rat adipose tissue and liver phosphopyruvate carboxylases that was maintained for 48h. The response of adipose tissue phosphopyruvate carboxylase was blocked by actinomycin D, corticosteroids and propranolol, whereas corticosteroids and propranolol did not affect the liver enzyme. Cortisol phosphate, like actinomycin D, interfered only with ...

The properties of the microsomal vitamin K-dependent carboxylase from the livers of the adult ox and dicoumarol-treated calf were investigated. The enzymes from both sources utilized glutamic residues of synthetic peptides as substrates and could be solubilized with Triton X-100 similarly to the enzyme from vitamin K-deficient rat liver. Under the optimal assay conditions, the microsomes from c...