Background: Magnetic resonance signal intensity of focal liver lesions is affected by numerous pathologic factors. Lesion histologic features, such as cellularity, vascularity, stromal component, and intratumoral necrosis or hemorrhage, strongly affect T1 and T2 relaxation times. Aim: Our study is done to assess the lesion characterization potential of MRI by evaluating unenhanced and dynamic g...

MRI has provided important insights into the pathophysiology of multiple sclerosis (MS).1 However, conventional MRI scans furnish only gross estimates of the nature and extent of tissue damage associated with MS,2 and the data correlate poorly with measures of concurrent disability in patients. Recent advances in MRI technology have improved the correlation of MRI findings with clinical status ...

T. Parikh, S. Drew, S. Wong, V. S. Lee, E. M. Hecht, R. Lim, B. Taouli Radiology, NYU Medical Center, New York, NY, United States Introduction: Current MRI techniques for assessing liver lesions include T2-weighted imaging (T2WI) and dynamic gadolinium-enhanced T1-weighted imaging. Accurate lesion detection and characterization are very important especially in patients with cirrhosis or cancer....

OBJECTIVE To evaluate the clinical application of phased-array surface coil intensity correction in magnetic resonance imaging (MRI) in spinal metastases. METHODS 3 phantoms and 50 patients with a corresponding total number of 80 spinal metastases were included in this study. Fast spin echo T1- and T2- weighted MRI with and without surface coil intensity correction was routinely performed for...

Introduction: High resolution MRI at 7T suggests that T2* contrast may be sensitive to white matter composition and microstructure [1]. Preliminary histological and MRI results show that the T2* heterogeneity in white matter may be in part reflect its myelin content [2]. In this study, the quantitative correlation between T2* relaxation rate (R2*=1/ T2*) and diffusion fractional anisotropy (FA)...

Advanced MRI studies demonstrated several diffuse non-lesional features in multiple sclerosis, including changes detectable in gray matter areas. Standard T2 weighted MRI scans of deep gray matter structures, including the thalamus, caudate, putamen, dentate nuclei often demonstrate hypointensity. T2 hypointensity has been shown to correlate with cognitive, neuropsychiatric and motor dysfunctio...

MRI has recently been applied to study the retina in vivo. Measurements of relaxation time constants (T1, T2, and T2*) and the apparent diffusion coefficient (ADC) of the retina would be useful to systemically optimize structural, physiological, and functional MRI contrasts. MRI studies were performed on 12 anesthetized and paralyzed rats. High-resolution T1, T2, T2* and ADC of the rat eyes wer...

Background: Conventional T2W imaging alone has a poor sensitivity for prostate cancer detection. This study therefore evaluated combined T2-W and diffusion weighted (DW)-MRI vs. T2-W MRI alone for identifying tumour in patients with prostate cancer. Material and Methods: 54 consecutive patients with prostate cancer (46 Stage 1 and 2, 8 stage 3) and sextant biopsies within the previous 3 months ...

Chronic blood transfusion is the only treatment for severe anemia in patients with β-thalassemia major. However, red blood cell transfusions lead to iron overload and subsequent organ damage because of the toxic effects of iron. The heart is particularly vulnerable to iron toxicity, and heart failure is the leading cause of death among these patients. Iron chelation therapy prevents or reverses...