Chlorambucil is an anticancer drug with alkylating and immunosuppressive properties. The present findings show that the combination treatment of tumor-bearing mice with ascorbic acid plus chlorambucil has much better therapeutic efficacy against murine ascites Daltons’ lymphoma in comparison to chlorambucil alone and this may involve a decrease in GSH in Dalton's lymphoma tumor cells. Chlorambu...

The present study determines the efficacy of N-acetyl cysteine (NAC) on marker enzymes, lipid peroxidation and antioxidants in carbon tetrachloride induced hepatotoxicity in rats. Carbon tetrachloride (CCl4) (3 mL/kg/week) administered subcutaneously to albino Wistar rats for a period of three months significantly increased the activities of marker enzymes in plasma such as aspartate transamina...

UNLABELLED Ischemia-reperfusion (I/R) damage is known to be a pathological process which continues with the increase of oxidants and expands with the inflammatory response. There is not any study about protective effect of etoricoxib on the liver I/R damage in literature. OBJECTIVE This study investigates the effect of etoricoxib on oxidative stress induced by I/R of the rat liver. MATERIAL...

Chlorambucil is an anticancer drug with alkylating and immunosuppressive properties. The present findings show that the combination treatment of tumor-bearing mice with ascorbic acid plus chlorambucil has much better therapeutic efficacy against murine ascites Daltons’ lymphoma in comparison to chlorambucil alone and this may involve a decrease in GSH in Dalton's lymphoma tumor cells. Chlorambu...

The present study was designed to observe the protective effect and mechanisms of meloxicam on liver injury caused by chronic aluminium exposure in rats. The histopathology was detected by hematoxylin-eosin staining. The levels of prostaglandin E2, cyclic adenosine monophosphate and inflammatory cytokines were detected by enzyme linked immunosorbent assay. The expressions of cyclooxygenases-2, ...

Cocaine is a commonly abused illicit drug that causes significant morbidity and mortality. The most severe and common complications are seizures, ischemic strokes, myocardial infarction, and acute liver injury. Here, we demonstrated that acute cocaine intoxication promoted seizure along with acute liver damage in mice, with intense inflammatory infiltrate. Considering the protective role of the...

Objective(s): Nanotechnology has enabled researchers to synthesize nanosize particles that possess increased surface areas. Compared to conventional microparticles, it has resulted in increased interactions with biological targets.The objective of this study was to determine the protective ability of selenium nanoparticles compared to selenium against parasetamol hepatotoxicity and GPX concentr...

Background: Theanine, which is hydrolyzed into glutamic acid (Glu), excerts beneficial effects on organ metabolism. However, there is little scientific evidence that Glu influences inflammatory mediator such as tumor necrosis factor (TNF)-α and nitric oxide (NO).In inflamed liver, proinflammatory cytokines stimulate liver cells, followed by the induction of inducible NO synthase (iNOS). Excessi...

acrolein (acr) is α, β unsaturated aldehyde that exists extensively in the environment and (thermally processed) foods. it can also be generated through endogenous metabolism. the aim of this study was to investigate the possible protective role of pentoxifylline (ptx) is a non-selective phosphodiesterase (pde) inhibitor on toxicity of acr. in this study, oxidative damage were measured by marke...

ricinus communis linn. (euphorbiaceae) is a soft wooded tree widely prevalent throughout tropics regions of the world which have a warm temperature. in the indian system of medicine, the leaves, roots and seed oil of this plant have been used for the treatment of inflammation and liver disorders for a long time. in the present study, the protective effects of ethanol extract of ricinus communis...