1. The influence of Ca2+ on the polymorphic phase behaviour of cardiolipin has been investigated employing 31P NMR and freeze-fracture techniques. The close correlation between the results obtained here and previous X-ray studies (Rand, R.P. and Sengupta, S. (1972) Biochim. Biophys. Acta 255, 484--492) confirms 31P NMR as a useful analytical procedure for investigating the polymorphic phase beh...

The effects of i.v. and local anaesthetics on guineapig tracheal smooth muscle have been investigated in vitro. Diazepam, propanidid and ketamine induced relaxation and antagonized histamine-, acetylcholine-and potassium chloride-induced contractures in the tracheal smooth muscle. The relaxing effects of the anaesthetics were not affected by propranolol. Thiopentone, at concentrations which wou...

Following our previous investigations on certain new aminoalkyl aryl ethers, which showed promising and outstanding local anaesthetic properties, the local anaesthetic activity and duration of action of a further selection of four novel derivatives of the above-mentioned series, used as hydrochloride salts, have been determined by the ill vivo rat sciatic nerve test. These are: N,N-dimethyl...