background: the effect of ovariectomy and accompanying sudden loss of circulating gonad hormones on spatial learning performance in the young adult rats was examined. we hypothesized that spatial learning and memory in a considerable number of women who undergo a surgical menopause and estrogen deprivation before their natural menopause be impaired. methods: in this study, we used 26 wistar rat...

background:estrogens play a substantial role in the proliferation, progression and treatment of breast cancer by binding with two estrogen receptors, alpha and beta (erα and erβ). resistance to endocrine therapy is a major problem in the treatment of breast cancers and, in some cases, may be related to loss of er gene expression. we have already showed that erα methylation occurs in high freque...

background and objective: angiogenesis is a complex program of several steps and it is tightly regulated by pro- and anti-angiogenic factors. angiogenesis is one of the key elements in cutaneous wound healing and skin cancers. estrogen seems to have positive modulating effect on cutaneous wound healing and this effect may be explained by its angiogenic properties. this study aims to investigate...

A single gene encodes the key enzyme for estrogen biosynthesis termed aromatase, inhibition of which effectively eliminates estrogen production. Aromatase inhibitors successfully treat breast cancer and endometriosis, whereas their roles in endometrial cancer, uterine fibroids, and aromatase excess syndrome are less clear. Ovary, testis, adipose tissue, skin, hypothalamus, and placenta express ...

Over the past two decades, the female hormone 17b-estradiol (estrogen) has emerged as an important contributor to energy homeostasis in both males and females. Early clinical evidence involved the observation that men lacking estrogen synthesis secondary to mutations in aromatase—the enzyme that converts androgen to estrogen—or men harboring estrogen resistance secondary to mutation of the estr...

Pyogenic granuloma (PG) is a benign vascular tumor that usually occurs on the skin and mucous membranes, mostly of oral cavity. The most common site for PG gingiva. lesion arises in response to various stimuli, such as low-grade local irritation, traumatic injury, or hormonal changes. It may occur at any age, with highest incidence 2nd 5th decades life. Women are more frequently affected due in...

This study was conducted to see the effects of Clomiphene Citrate on fertility hormones estrogen, progesterone, LH, FSH in patients with infertility associated polycystic ovary syndrome. For this fifty infertile PCOS who were given treatment clomiphene citrate (50–150mg/day for 5 days). Ovarian response ovulation monitored by transvaginal ultrasonography and serum levels FSH, estrogen also esti...

introduction: due to the risks of hormones on human health and aquatic life, the aims of this study were to determine the efficiency of estrogen removal in the different stages of shiraz wastewater treatment plant using activated sludge process and marvdasht wastewater treatment plant using aerated lagoons process and also comparing the performance of both systems in removing the hormone of est...