In the next few years, Brazil will host international events such as the 2014 FIFA World Cup and the 2016 Olympics Games. Given the worldwide appeal of these events, local authorities in Brazil expect the country will have around 1.6 million visitors arriving at its airports (1 million for the Olympics and 600 thousand for the World Cup). Therefore, these events will put to test the robustness ...

The niche directs key behaviors of its resident stem cells, and is thus crucial for tissue maintenance, repair and longevity. However, little is known about the genetic pathways that guide niche specification and development. The male germline stem cell niche in Drosophila houses two stem cell populations and is specified within the embryonic gonad, thus making it an excellent model for studyin...

Microarray data were collected from bile duct samples from subjects with malignant biliary strictures by endoscopic retrograde cholangiopancreatography to screen for key genes associated with this disease. A predicted interaction network was constructed for these genes to interpret their functions. The gene expression dataset GSE34166 (10 samples: 6 malignant and 4 benign control samples) was d...

0377-2217/$ see front matter 2011 Elsevier B.V. A doi:10.1016/j.ejor.2011.01.014 ⇑ Tel.: +90 312 290 27 68; fax: +90 312 266 40 54. E-mail address: [email protected] In this paper, we study allocation strategies and their effects on total routing costs in hub networks. Given a set of nodes with pairwise traffic demands, the p-hub median problem is the problem of choosing p nodes as hub loca...

In this paper the capacitated hub location problem is formulated by a minimax regret model, which takes into account uncertain setup cost and demand. We focus on hub location with multiple allocations as a strategic problem requiring one definite solution. Investigating how deterministic models may lead to sub-optimal solutions, we provide an efficient formulation method for the problem. A comp...

We investigated the effects of eribulin and paclitaxel on breast cancer (BC) by exploring molecular biomarkers and pathways. Co-expression networks were constructed by differentially co-expressed genes and links, and centralities were analyzed to explore the hub genes. Pathway-enrichment analysis was performed. The hub genes were validated using the polymerase chain reaction and western blottin...

We first define and experiment the hub-authority core (or HA-core) of a directed network. It depends on two a and h parameters expressing requirements on hub and authority degrees which have to be fulfilled within the core. The definition of these interrelated degrees is inspired by the standard definition of hub and authorities centrality scores (HITS). We investigate the HA-cores on citation ...

We study stochastic uncapacitated hub location problems in which uncertainty is associated to demands and transportation costs. We show that the stochastic problems with uncertain demands or dependent transportation costs are equivalent to their associated deterministic expected value problem (EVP), in which random variables are replaced by their expectations. In the case of uncertain independe...