Osteoporosis is a systemic skeletal disease characterised by loss of bone mass and microarchitectural integrity that lead to increased bone fragility and risk of fracture.' Its natural history is one of slow, progressive bone loss that often remains asymptomatic and undiagnosed for many years. Only when a substantial amount of bone has been lost do the characteristic low trauma fractures occur....

BACKGROUND The human body has an extensive capacity to regenerate bone tissue after trauma. However large defects such as long bone fractures of the lower limbs cannot be restored without intervention and often lead to nonunion. Therefore, the aim of the present study was to assess the pool and biological functions of human mesenchymal stromal cells (hMSCs) isolated from different bone marrow l...

Background and purpose - The AO Pediatric Comprehensive Classification of Long Bone Fractures (PCCF) describes the localization and morphology of fractures, and considers severity in 2 categories: (1) simple, and (2) multifragmentary. We evaluated simple and multifragmentary fractures in a large consecutive cohort of children diagnosed with long bone fractures in Switzerland. Patients and metho...

BACKGROUND Alendronate is a bisphosphonate that is approved to reduce bone loss in glucocorticoid treated patients. In this paper, we present a case of femoral fracture following the use of Alendronate. CASE PRESENTATION A- 46 year old woman who was a known case of hemolytic anemia has been treated by prednisolone (with different doses from 7.5 to 75 mg/day), calcium-D 500 mg/day and alendron...

About one in three osteoporotic fractures occur in men, and the consequences of fractures are more severe in men. However, only too few men at high risk of fracture are detected and treated. There is no consensus definition of osteoporosis in men based on bone mineral density (BMD), and therapeutic decisions should be based on absolute fracture risk as estimated from age, BMD, fracture history,...

Tibial shaft fracture is a common orthopaedic and trauma condition. Incidence of tibial fracture is average 26 in 100,000 per year at the age of 15 to 19 years. It is more common in US that is 109 in 100,000 per year [1]. Operative treatment options are external fixation, open reduction and internal fixation with plate and screws or intramedullary nailing. Intramedullary nailing is widely accep...

Breast cancer is the most commonly diagnosed cancer among women, but despite survival rates improvement, it is still the second major cause of cancer related death. In postmenopausal women with estrogen receptor (ER) dependent breast cancer, hormone therapy is an option, either by direct inhibition of ER using tamoxifen or by aromatase inhibition, resulting in decreased estrogen production. In ...

Although the chances of predicting a preventable fracture by bone densitometry may be small, it is also important that two thirds of patients can be reassured that fracture is less likely and therefore long term treatment is not needed. That there is overuse, overdiagnosis, and overtreatment for osteoporosis is due not to bone densitometry or to epidemiological reports but to various factors, i...

conclusions the functional outcome 22 months post injury showed that although primary treatment method uses locked imn in humeral shaft fractures, unlocked imn can be used in appropriate cases. less injury risk to the axillary and radial nerve, short period of surgery, and less radiation can be considered as advantages of this technique. introduction although intramedullary nailing (imn) is use...

Background. The proximal femur is a frequent location of bone metastases, and pathological fractures in this area are common. A pathological fracture and/or pain associated with bone destruction are indications for surgery. Among many methods of surgical treatment, partial resection and subsequent arthroplasty appears to be the most efficient. The low cost of the implant and the relatively simp...