Charles W. O’Connell, MD, Amir A. Schricker, MD, MS, Aaron B. Schneir, MD, Imir G. Metushi, PhD, Ulrika Birgersdotter-Green, MD, Alicia B. Minns, MD From the Division of Medical Toxicology, Department of Emergency Medicine, University of California San Diego, San Diego, California, Department of Emergency Medicine, Veterans Association San Diego, La Jolla, California, Division of Cardiovascular...

Objectives: The main objective of the study was to explore in-vivo anti-diarrheal properties Methanol, Ethanol, Hot and Coldwater fractions Cassia abbreviata (Fabaceae) stem bark in mice model order validate its traditional use.
 Study Design: This an experimental based study, where we used 30 Swiss albino these were divided into five groups six mice.
 Methods: test (group three, four...

This paper shows a new finding about the decrease of relaxative response to loperamide in prostate of spontaneously hypertensive rats (SHR) as compare to normal rats (WKY). Authors demonstrated the reduction of ATP-sensitive potassium channels is responsible for this change using immunoblotting analysis and the decrease of action induced by diazoxide. This view is not mentioned before and is th...

Methods The ethyl acetate extract of Pedalium murex L., (250, 500, and 1000 mg/kg body weight) was administered orally to three groups of rats (five animals per group) in order to evaluate the activity of the extract against castor oil-induced diarrhea model in rat. Two other groups received normal saline (5mg/kg) and loperamide (5mg/kg) as positive control. The effect of the extract on intesti...

Direct Inhibition of Ih by Analgesic Loperamide in Rat DRG Neurons Dmitry V. Vasilyev, Qin Shan, Yan Lee, Scott C. Mayer, Mark R. Bowlby, Brian W. Strassle, Edward J. Kaftan, Kathryn E. Rogers, John Dunlop Discovery Neuroscience and Chemical and Screening Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543-8000 Page 1 of 37 Articles in PresS. J Neurophysiol (March 28, 2007). doi:10.1152/jn.0...