Meningococcal lipopoly(oligo)saccharide (LOS) is a major inflammatory mediator of fulminant meningococcal sepsis and meningitis. Highly purified wild-type meningococcal LOS and LOS from genetically defined mutants of Neisseria meningitidis that contained specific mutations in LOS biosynthesis pathways were used to confirm that meningococcal LOS activation of macrophages was CD14/Toll-like recep...

Spontaneous antigenic and phenotypic variations in the lipooligosaccharide (LOS) of two strains of Haemophilus influenzae type b (Hib) were previously shown to be associated with changes in virulence (A. Kimura and E.J. Hansen, Infect. Immun. 51:69-79, 1986). The goal of the present study was to define further the stability of LOS expression by this pathogen and the role of Hib LOS in virulence...

INTRODUCCIÓN Los médicos y la industria farmacéutica comparten el objetivo del progreso en el conocimiento científico; sin embargo, el principal interés del médico es proporcionar a sus pacientes el mejor tratamiento posible, mientras que el principal interés de la industria es vender su producto. La industria farmacéutica colabora en el desarrollo de importantes avances en medicina y tecnologí...

Christa N. Grant, Salvador Garcia Mojica, Frederic G. Sala, J. Ryan Hill, Daniel E. Levin, Allison L. Speer, Erik R. Barthel, Hiroyuki Shimada, Nicholas C. Zachos, and Tracy C. Grikscheit Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children’s Hospital Los Angeles, Los Angeles, California; Division of Pediatric Surgery, Children’s Hospital Los Angeles, USC ...

En 2015, la Sociedad Española de Salud Pública y Administración Sanitaria (SESPAS) y la Organización Médica Colegial (OMC) constituyeron un grupo de trabajo sobre iatrogenia, entendida (de causado [genus] por el médico [iatros]) como el daño a pacientes y ciudadanos infligido por el sistema sanitario, que trasciende las actuaciones clínicas individuales de prevención, diagnóstico, tratamiento o...

Title: 1 Intra-Uterine Calorie Restriction Affects Placental DNA Methylation and Gene 2 Expression 3 4 Pao-Yang Chen1, Amit Ganguly2, Liudmilla Rubbi3, Luz D. Orozco3, Marco Morselli3, 5 Davin Ashraf3, Artur Jaroszewicz3, Suhua Feng3, Steve E. Jacobsen3,4, Atsushi 6 Nakano3,5,6,7, Sherin U. Devaskar2 & Matteo Pellegrini3,5,6,8* 7 Affiliations 8 1. Institute of Plant and Microbial Biology, Acade...

Endotoxins represent one of the most potent classes of microbial immunoactive components that can cause pulmonary inflammation. The aim of this study was to compare the inflammatory potency of two types of Neisseria meningitidis endotoxins (lipooligosaccharides) in lungs: wild type (hexaacylated, LOS(wt)) and mutant type (pentaacylated, LOS(msbB)), and to determine the importance of MD-2 in end...

Embryos generated with the use of assisted reproductive technologies (ART) can develop overgrowth syndromes. In ruminants, the condition is referred to as large offspring syndrome (LOS) and exhibits variable phenotypic abnormalities including overgrowth, enlarged tongue, and abdominal wall defects. These characteristics recapitulate those observed in the human loss-of-imprinting (LOI) overgrowt...

Objetivo. Evaluar la asociación entre la exposición a los principales contaminantes químicos del agua de consumo humano (ACH) y el aumento de casos de cáncer en menores de 19 años. Métodos. Se realizó una revisión sistemática de la literatura científica recogida en las bases de datos MEDLINE (via PubMed©), EMBASE©, Web of Knowledge, Cochrane Library Plus, Literatura Latinoamericana y del Caribe...

Eventos adversos relacionados con la medicación en los ancianos atendidos en urgencias Drug-induced adverse events in elderly persons presenting to the emergency department (Screening Tool of Older Persons' Prescriptions) y START (Screening Tool to Alert doctors to Right Treatment), que son herramientas de utilidad a la hora de la prescripción terapéutica en los pacientes de edad avanzada. Cual...