BACKGROUND Pexmetinib (ARRY-614) is a dual inhibitor of p38 mitogen-activated protein kinase and Tie2 signaling pathways implicated in the pathogenesis of myelodysplastic syndromes. Previous clinical experience in a Phase I dose-escalation study of myelodysplastic syndrome patients using pexmetinib administered as neat powder-in-capsule (PIC) exhibited high variability in pharmacokinetics and e...

The introduction of electrolytic aluminum load in a large-scale power system with complex station structure is essential for frequency control (LFC). In this paper, we propose strategy to participate the modulation grid based on IEEE standard two-region LFC model. Besides, fractional-order PID (FOPID) controller designed and compared traditional PID, parameters FOPID are optimized by PSO algori...

PURPOSE This study examined preschool teachers' fidelity to the language-focused curriculum (LFC; B. Bunce, 1995), a comprehensive classroom curriculum designed to improve at-risk children's language outcomes through targeted improvements to a classroom's activity contexts (e.g., dramatic play, art, storybook reading) and instructional processes (e.g., teacher use of open-ended questions, recas...

This paper proposes a unified frame work for identification and control using time moments(TM) in which delta operator is used. Dynamic systems modelling with delta operator provides a unified framework in rapprochement between discrete-time systems and its continuous-time counterpart at fast sampling The theory of delta time moments(DTM) is utilized to develop algorithms for load frequency con...

In this paper a new evolutionary computing method based on imperialist competitive algorithm (ICA) is used for tuning the parameters of a PID controller which is applied in a load frequency control system (LFC) in a multi area electric power system. If a large power imbalance is suddenly happened in a multi area power electric system, generation units and also consumer sides will be affected by...

Renewable energy provides 20% of electricity generation worldwide. Hydroelectric power is the cheapest way to generate electricity today. It provides almost onefifth of the electricity in world. Hydropower is produced in more than 150 countries. The main objective of this paper is modelling and analysis of the effects of the power system stabilizer (PSS) for load frequency control (LFC) system ...

In this paper, a Reliable Multicast transport protocol over combined (fixed/mobile) networks using Sub Sub-casting called (RMSS) is proposed. RMSS is based on a hierarchical structure where receivers are grouped into local regions. In each local region there are special receivers, which are called Designated Receivers (DRs) and Mobile Agents (MAs). Each DR or MA is responsible for retransmissio...

In this paper a Fuzzy Logic based load frequency control system (LFC) with Superconductor Magnetic Energy Storage System (SMES) in a multi area electric power system was explained. If a large power imbalance is suddenly happened in a multi area power electric system, generation units and also consumer sides will be affected by the distortion in the energy balance between both two sides. This im...

Lactoferrin has antimicrobial activity associated with peptide fragments lactoferricin (LFC) and lactoferrampin (LFA) released on digestion. These two fragments have been expressed in Photorhabdus luminescens as a fusion peptide linked to protein cipB. The construct cipB-LFC-LFA was tested as an alternative to antimicrobial growth promoters in pig production. Sixty piglets with an average live ...