background: the aim was to investigate the relationships among lean mass (lm), fat mass (fm), and bone mineral density (bmd) in women stratified by body mass index (bmi) (bmi – normal-weight, overweight, obese) and to determine threshold at which body fat assumes negative relationship with bmd. methods: this was a cross-sectional study in 471 healthy caucasian women, aged 18-67 years. bmd, lm, ...

introduction : acute lymphoblastic leukemia (all) and non-hodgkin's lymphoma (nhl) are the most common malignancies in children and adolescents. therapies such as corticosteroids, cytotoxic and radiotherapy will have harmful effect on bone mineral density (bmd) which can lead to increased possibility of osteoporosis and pathological fractures. subjects and methods: this 3-year cross-sectional s...

BACKGROUND AND OBJECTIVES Darker skin pigmentation and aging are known factors influencing the body's ability to synthesize adequate amounts of vitamin D (25OHD). The objective of this study is to determine the 25OHD insufficiency in elderly African American females of low socioeconomic status (SES) in a southern latitude during springtime sun exposure. METHODS Patients >or= 70 years old who ...

We investigated the effect of locally administered bisphosphonate on distraction osteogenesis in a rabbit model and evaluated its systemic effect. An osteotomy on the right tibia followed by distraction for four weeks was performed on 47 immature rabbits. They were divided into seven equal groups, with each group receiving a different treatment regime. Saline and three types of dosage of alendr...

OBJECTIVE To investigate the effects of two doses of vitamin D given over 1 year on bone density in ambulatory patients on long-term antiepileptic drug (AED) therapy. METHODS We conducted two parallel, randomized, controlled trials in 72 adults (18 to 54 years old) and 78 children and adolescents (10 to 18 years) on long-term AED therapy. They received either low-dose vitamin D 400 IU/day or ...

CONTEXT Calcium Nephrolithiasis is a multifactorial disease; in its pathophysiology is involved various minerals and metabolic factors that may be altered, including bone and phosphor-calcium metabolism. OBJECTIVE To establish the scientific evidence and demonstrate the relationship between calcium nephrolithiasis and bone mineral density loss, through the use of bone turnover markers, serum ...

1. The influence of pregnancy, lactation and weaning on bone mineral density in healthy women was investigated during a 2 year prospective study of 59 pregnant and lactating women from the 18th week of gestation. 2. Bone mineral density was measured by dual energy X-ray absorptiometry at the non-dominant radius ultra distally and more proximally in the 18th and 37th weeks of gestation, and 0, 3...

BACKGROUND The study objectives were to determine fracture rates in relation to bone mineral density at various central skeletal sites, using the World Health Organization definition for osteoporosis (T-score -2.5 or less), and to contrast fracture patterns among women 50 to 64 years of age with those among women 65 years of age and older. METHODS Historical cohort study with a mean observati...

INTRODUCTION Calcium and vitamin D malabsorption in coeliac disease (CD) predispose to skeletal demineralisation. The aim of this study was to evaluate the prevalence of bone mineral density (BMD) and calcium deficiencies in adult patients with CD and assess whether a gluten-free diet is sufficiently effective for BMD restoration. MATERIAL AND METHODS BMD and biochemical parameters of bone an...

Osteoporosis is a major public health problem in Western countries and is projected to have a similar impact in the Middle East. It has been suggested that peak bone mineral density (BMD), a major determinant of osteoporotic fractures later in life, may be lower in this part of the world compared with the Western world. However, subjects have not been randomly selected or systematically screene...