Background: Dyslipidemia is considered an independent risk factor for coronary heart disease (CHD). In the present study, we examined lipid profiles and paraoxonase 1 (PON1) activity and atherogenic indexes status and the relationship of PON1 activity by high-density lipoprotein (HDL) and atherogenic indexes in CHD patients and healthy people. Methods: The aim of the study was to compare PON...

References 1. Kataoka H, Kume N, Miyamoto S, Minami M, Moriwaki H, Sawamura T, et al. Expression of lectin-like oxidized low density lipoprotein receptor-1 in human atherosclerotic lesions. Circulation 1999;99:3110–7. 2. Kume N, Kita T. Roles of lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) and its soluble forms in atherogenesis. Curr Opin Lipidol 2001;12:419–23. 3. Murase T, ...

Eight monoclonal antibodies (Mabs) to human serum low density lipoprotein (LDL) were derived from the fusion of spleen cells, from LOU rats immunized with human LDL, and the rat myeloma line IR983F. These Mabs were characterized in terms of isotype, specificity, and affinity. Competitive experiments indicated that the epitopes that were recognized could be grouped into three patterns depending ...

In a group of 303 healthy Caucasian adults of both sexes we studied the influence of the apolipoprotein E (apo E) polymorphism on plasma levels of Lipoprotein(a) (Lp(a). The APOE*2 allele was found to decrease the mean plasma Lp(a) level by 24.8%, whereas the APOE*4 allele increased the mean Lp(a) level by 25.7%. These effects were parallel to the effect of apo E polymorphism on plasma choleste...

Dyslipidemia is a disease characterized by abnormalities in blood lipid levels, mainly total cholesterol and triglycerides. Other changes include low high-density lipoprotein (HDL-C) high levels of low-density (LDL-C)

Steroidogenic cells utilize lipoprotein-delivered cholesterol as a primary substrate for hormone synthesis. We studied low density lipoprotein (LDL) receptors in cultured human granulosa cells to determine what factors regulate receptor expression. Granulosa cells cultured under serum-free conditions were treated with human chorionic gonadotropin (hCG) for 1.5 to 14 hr. The LDL receptor content...

Hypercholesterolemia is a known major risk factor in the development of athereosclerosis [29, 32, 51]. This circumstance is caused by internal homeostasis due to foods consumed. The hypercholesterolemia may be related to high cholesterol diet or regular saturated fatty acids intake [42]. The incidence of Chronic Heart Disease (CHD) remains high despite blood pressure being controlled in hyperte...

Submit Manuscript | http://medcraveonline.com Abbrevations: PCOS: Polycystic Ovary Syndrome; OCPs: Oral Contraceptive Pills; HA: Hyper androgenic Anovulation; SHBG: Sex-Hormone Binding Globulin; LDL: Low-Density Lipoprotein; HDL: High-Density Lipoprotein; HTN: Hypertension; AR: Androgen Receptor; LH: Luteinizing Hormone; VNTR: Variable Number of Tandem Repeats; TNF-alpha: Tumor Necrosis Factora...