Elucidating the biological effect of low linear energy transfer (LET), low-dose and/or low-dose-rate ionizing radiation is essential in ensuring radiation safety. Over the past two decades, non-targeted effects, which are not only a direct consequence of radiation-induced initial lesions produced in cellular DNA but also of intra- and inter-cellular communications involving both targeted and no...

Current guidelines for limiting exposure of humans to ionizing radiation are based on the linear-no-threshold (LNT) hypothesis for radiation carcinogenesis under which cancer risk increases linearly as the radiation dose increases. With the LNT model even a very small dose could cause cancer and the model is used in establishing guidelines for limiting radiation exposure of humans. A slope chan...

The statistical difficulties of estimating cancer risks from low doses of a carcinogen are illustrated by examples from radiation carcinogenesis. Although more is known about dose-response relationships for ionizing radiation than for any other environmental carcinogen, estimates of cancer risk from low radiation doses have been extremely controversial; disagreements by factors of 100 or more a...

BACKGROUND Risks of most types of leukemia from exposure to acute high doses of ionizing radiation are well known, but risks associated with protracted exposures, as well as associations between radiation and chronic lymphocytic leukemia (CLL), are not clear. OBJECTIVES We estimated relative risks of CLL and non-CLL from protracted exposures to low-dose ionizing radiation. METHODS A nested ...

An opportunity to use laser radiation as a means to reduce negative aftermath of acute and prolonged exposure to ionizing radiation was checked. The mice were exposed to γrays of Со (whole body irradiation) in the dose of 7 Gy (the transitional clinical form of the acute radiation sickness). The dose rate at acute irradiation was 1.14 Gy/min, and at prolonged exposure, 0.027 Gy/min. Laser radia...

ionizing radiation causes dna damage and chromosome abbreviations on normal cells. the radioprotective effect of celecoxib (clx) was investigated against genotoxicity induced by ionizing radiation in cultured human blood lymphocytes. peripheral blood samples were collected from human volunteers and were incubated at different concentrations at 1, 5, 10 and 50 μm of clx for two hours. at each do...

Fractionated, high-dose total body irradiation (TBI) is used therapeutically to myeloablate and immune suppress patients undergoing hematopoietic stem cell (HSC) transplantation. Acute exposure to ionizing radiation can have fatal effects on the hematopoietic and immune systems. Currently, therapies aimed at ameliorating ionizing radiation-associated toxicities are limited. In the February 2014...

Introduction: Occupational exposure to ionizing radiation due to medical activities (both diagnostic and therapeutic procedures) has increased sharply in recent years. Among the occupationally exposed workers in these fields, those most affected by this increased exposure to ionizing radiation are nuclear medicine workers. In this study, annual average effective dose, annual collective effectiv...

BACKGROUND Radiation-induced bone sarcoma has been associated with high doses of ionizing radiation from therapeutic or occupation-related exposures. However, the development of bone sarcoma following exposure to lower doses of ionizing radiation remains speculative. METHODS A cohort analysis based on the Life Span Study (n = 120,321) was performed to assess the development of bone sarcoma in...

Advisory Group on Ionising Radiation. 2010. Circulatory Disease Risk. Report of the Independent Advisory Group on Ionising Radiation. London:Health Protection Agency. Available: http://www.hpa.org.uk/webc/HPAwebFile/ HPAweb_C/1284475204588 [accessed 8 November 2012]. Burnham KP, Anderson DR. 1998. Model Selection and Multimodel Inference: A Practical Information-Theoretic Approach. 2nd ed. New ...