INTRODUCTION Cardiac toxicity is one of the life-threatening complications of cancer therapy. Systemic anticancer treatments may exert their own toxic effects or can aggravate adverse effects of other drugs. We report a case of cyclophosphamide-induced cardiotoxicity in a patient with normal cardiac functions before chemotherapy. CASE PRESENTATION A 66-year-old Caucasian woman with a mediasti...

Background. Contrast ventriculograms of 542 patients treated with intravenous thrombolytic agents for acute myocardial infarction were examined to define changes in left ventricular ejection fraction and regional wall motion that occur during the first week after reperfusion therapy for acute myocardial infarction and define clinical, acute angiographic and treatment variables related to improv...

BACKGROUND Contrast ventriculograms of 542 patients treated with intravenous thrombolytic agents for acute myocardial infarction were examined to define changes in left ventricular ejection fraction and regional wall motion that occur during the first week after reperfusion therapy for acute myocardial infarction and define clinical, acute angiographic and treatment variables related to improve...

t1 TITLE (include Security Classi kation) REST AND EXERCISE LEFT VENTRICULAR EJECTION FRACTION BEFORE AND AFTER THERAPY IN YOUNG ADULTS WITH HYPERTHYROIDISM AND HYPOTHYROIDISM 12. PERSONAL AUTHOR(S) R.C. SMALLRIDGE, M. H. GOLDMAN, K.RAINES, S. JONES, AND D.V. NOSTRAND 137 TYPE OF REPORT ' Ib TIME COVERED 14 DATE OF REPORT (Year. Month, Day) 15 PAGE COUNT Manuscript I FROM TO 16 SUPPLEMENTARY NO...

To determine whether endurance exercise training can improve left ventricular systolic function in older men, 10 healthy sedentary men (64 +/- 3 years old; mean +/- SD) were studied. Training consisted of endurance exercise 4 +/- 0.3 days per week for 11.8 +/- 2.5 months at a progressively increasing intensity of 60-80% of maximal O2 uptake (Vo2max) with additional brief bouts of exercise equal...

BACKGROUND Prophylactic defibrillator implantation is recommended in dilated, nonischemic heart disease and left ventricular ejection fraction of ≤0.30 to 0.35. Noninvasive testing should improve accuracy in decision making of prophylactic defibrillator implantation. METHODS AND RESULTS We enrolled 60 patients (median age, 57 years) with dilated cardiomyopathy and left ventricular ejection fr...

Introduction: Cardiac toxicity is one of the life-threatening complications of cancer therapy. Systemic anticancer treatments may exert their own toxic effects or can aggravate adverse effects of other drugs. We report a case of cyclophosphamide-induced cardiotoxicity in a patient with normal cardiac functions before chemotherapy. Case presentation: A 66-year-old Caucasian woman with a mediasti...