Type II heat-labile enterotoxin (LT-II) from Escherichia coli causes characteristic morphological changes and accumulation of cyclic AMP in Y-1 adrenal cells, but it is not neutralized by antisera against choleragen (CT) or the classical type I heat-labile enterotoxin (LT-1) from E. coli. The action of purified LT-II on CT- and LT-I-responsive human fibroblasts was investigated and compared wit...

Surface lymphotoxin (LT) is a heteromeric complex of LT-alpha and LT-beta chains that binds to the LT-beta receptor (LT-beta-R), a member of the tumor necrosis factor (TNF) family of receptors. The biological function of this receptor-ligand system is poorly characterized. Since signaling through other members of this receptor family can induce cell death, e.g., the TNF and Fas receptors, it is...

Cholera toxin (CT) and the heat-labile enterotoxin of Escherichia coli (LT-I) are members of the serogroup I heat-labile enterotoxins (HLT) and can serve as systemic and mucosal adjuvants. However, information is lacking with respect to the structurally related but antigenically distinct serogroup II HLT, LT-IIa and LT-IIb, which have different binding specificities for ganglioside receptors. T...

statement of problem: condylar hyperplasia of the mandible is a self limiting abnormality which can cause facial asymmetry, temporomandibular joint (tmj) dysfunction and esthetic problems. treatment planning is based on the results of isotope scanning, clinical findings and patient age. single photon emission tomography (spect) is considered to be a sensitive method in the calculation of condyl...

<p style='text-indent:20px;'>The intersection of a linear code and its dual is called the hull this code. The complementary (LCD) if dimension zero. In paper, we develop method to construct LCD codes with one-dimensional by association schemes. One constructions in paper generalizes that associated Gauss periods given [<xref ref-type="bibr" rid="b5">5</xref>]. addition, presen...

Background The outcome of pediatric deceased donor liver transplantation (LT) has not been well studied, especially pediatric deceased donor livers used in adult transplantation. This study aimed to evaluate the efficacy of LT using pediatric deceased donor livers and compare the outcomes between pediatric-to-pediatric LT and pediatric-to-adult LT. Methods A retrospective review of LT using p...

Asymmetric ion channels are formed in a bimolecular lipid membrane by beta-latrotoxin (LT) introduced to one (cis) side of the membrane. LT-specific antibodies added to the opposite (trans) side of the membrane block the current through the LT channels when a negative potential is applied to the cis side, no blockade is observed at positive potentials. LT-specific antibodies do not block the ch...

BACKGROUND Lung transplant (LT) aims to extend survival and improve patient-centred outcomes (PCOs) by reducing disability and improving health-related quality of life (HRQL). Few PCO instruments have been validated in LT populations. We aimed to develop and validate a shortened version of the valued life activities (VLA) disability scale specific to LT. METHODS We used data from 140 subjects...

The importance of lymphotoxin (LT ) in lymphoid organogenesis is well established. Although LT has been implicated in the pathogenesis of T-cell-mediated immunopathologies, the requirement for LT in T-cell activation and effector function in vivo is not well understood. To determine the role of LT in T-cell activation in vivo, we compared the generation of antigen-specific T-cell responses betw...

BACKGROUND Patients with sarcoidosis, many of whom are African American, may require lung transplantation (LT). Little is known about survival following LT for sarcoidosis. OBJECTIVE To determine short-term mortality following LT for sarcoidosis, to evaluate if survival after LT for sarcoidosis is similar to outcomes after LT for other diseases, and to investigate the impact of race on the re...