Determining the level of expiratory flow limitation (EFL) in critical mechanically ventilated patients is of clinical relevance for choosing appropriate respiratory treatment and/or pharmacological therapy. In many respiratory diseases, EFL arises from pathological changes in the mechanical properties of the bronchial tree. These properties cannot be evaluated using common lumped-parameter mode...

The medial portion of the cat's lateral posterior-pulvinar complex (LPm) receives a prominent ascending projection from the superficial layers of the superior colliculus. This region of the thalamus has been suggested to serve as a relay by which visual information from the midbrain could be conveyed to extrastriate cortex. In order to determine how the functional organization within the LPm co...

We evaluated whether lumped-parameter non-linear viscoelastic models of human fingertip tissue can describe fingertip force-displacement characteristics during a range of rapid, dynamic tapping tasks. Eight human subjects tapped with their index finger on the surface of a rigid load cell while an optical system tracked fingertip position using an infra-red LED attached to the fingernail. Four d...

In this paper, lumped-parameter models (LPMs) were developed and utilized to simulate nitrate concentration in the groundwater of Gaza City and Jabalia Camp (GCJC) in the Gaza Coastal Aquifer (GCA) in Palestine. In the GCJC area, nitrate levels exceed the maximum contaminant level (MCL) of 10 mg/L NO3-N (45 mg/L NO3) in many wells. Elevated nitrate concentrations in the groundwater of GCJC area...

Multidimensional systems describe relations between signals depending on two or more independent variables, like time and space. They are also called distributed parameter systems. The only conventional model for their description are partial diierential equations. This is in contrast to onedimensional (lumped parameter) systems, where a variety of diierent models including transfer functions i...

Water quality models combine fluid-flow relations with biological regressions, all on a spatially complex domain. For many applications, a computationally simple lumped parameter model with regressed parameters suffices, while for others where a more fundamental approach may be worth the extra development and computational effort. A simple example modelling the transport of salt in interconnect...

Exogenous application of BMP to the lateral plate mesoderm (LPM) of chick embryos at the early somite stage had a positive effect on Nodal expression. BMP applications into the right LPM were followed by a rapid activation of Nodal, while applications into the left LPM resulted in expansion of the normal domain of Nodal expression. Conversely, blocking of BMP signaling by Noggin in the left LPM...