Background: Androgen deprivation therapy (ADT) by surgical or medical castration is recommended for advanced or metastatic prostate cancer. Recent literature suggests that medical castration by luteinizing hormone receptor hormone (LHRH) antagonists might have advantages over treatment with LHRH agonists in patients with metastatic prostate cancer when prostate specific antigen (PSA) progressio...

Khosrow Adeli Clinical Biochemistry, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, M5G 1X8 Canada List of abbreviations: CALIPER, Canadian Laboratory Initiative on Pediatric Reference Intervals; RIDL, Reference Intervals and Decision Limits; IFCC, International Federation of Clinical Chemistry and Laboratory Medicine; CLSI, Clinical Laboratory Standards Institute; GGT...

OBJECTIVE Aneurysmal subarachnoid hemorrhage puts patients at high risk for the development of pituitary insufficiency. We evaluated the incidence of pituitary dysfunction in these patients and its correlation with clinical outcome. METHODS Pituitary function was tested in 66 consecutive patients in the first 15 days after aneurysmal subarachnoid hemorrhage. The following were measured in all...

Hypogonadotropic hypogonadism is defined as a medical condition with low or undetectable gonadotropin secretion, associated with a complete arrest of follicular growth and very low estradiol. The main cause can be traced back to an irregular or absent hypothalamic GnRH secretion, whereas only a minority suffers from a pituitary disorder. The choice of treatment to reverse this situation is a pu...