flavonoids are wide range of phytochemical with various pharmacological effects including antioxidant, anti-inflammation, anti-platelet, anti-allergic, cytotoxicity, reduce risk for heart disease or cancer etc. these flavonoids inhibited various enzymes such as prostaglandin synthase, lypoxygenase, cyclooxygenase, and induced detoxifying enzyme systems such as glutathione s-transferase. flavono...

The allergy-preventive activity of a 35% EtOH extract (IT) of flowers of Impatiens textori MIQ. was demonstrated in a continuing search for allergy-preventive substances from natural sources. The evaluation of its activity used an in vivo assay method for monitoring the blood flow decrease in the tail vein microcirculation of mice subjected to sensitization with hen-egg white lysozyme. Among th...

The molecular properties of apigenin, luteolin and nevadensin which are three naturally flavonoid compounds have been studied theoretically by DFT method at 6-311++G(d,p) level. Both FMO analysis, mechanism, kinetics suggested that compound Luteolin (compound 3) was a promising antioxidant agent. results indicated HAT is thermodynamically preferred in the gas phase, SPLET favorable pathway meth...

Cyclin G-associated kinase (GAK), a key player in clathrin-mediated membrane trafficking, is overexpressed in various cancer cells. Here, we report that GAK expression is positively correlated with the Gleason score in surgical specimens from prostate cancer patients. Embryonic fibroblasts from knockout mice expressing a kinase-dead (KD) form of GAK showed constitutive hyper-phosphorylation of ...

The hydromethanolic extract of Sapindus saponaria L. aerial parts was investigated for antimicrobial activity (against several Gram-positive and Gram-negative bacteria and fungi) and capacity to inhibit the growth of different human tumor cell lines as also nontumor liver cells. The evaluated extract was further characterized in terms of phytochemicals using UV, (1)H-NMR, (13)C-NMR, and MS spec...

Bioactivity-guided fractionation of the methanol extract from the leaves of Santolina insularis led to the isolation of one new xanthone, (E)-3-(6-[(E)-3-hydroxy-3-oxo-1-propenyl]-9-oxo-9H-xanthen-2-yl)-2-propenoic acid, together with six known flavonoids: hispidulin, nepetin, cirsimaritin, rhamnocitrin, luteolin and luteolin 7-O-beta-D-glucopyranoside. The structures were elucidated by means o...

Oral administration of the perilla leaf extract (PLE) to mice inhibits inflammation, allergic response, and tumor necrosis factor-alpha production. We also found that PLE suppressed the tumor necrosis factor-alpha (TNF-alpha) production in vitro. Using the inhibitory activity of TNF-alpha production in vitro as the index for isolation, we searched the active constituents from PLE and isolated l...

Soymida febrifuga (Roxb.) A. Juss. is an indigenous lofty deciduous medicinal tree, monotypic genus endemic to India. Hexane, ethyl acetate and methanol extracts of Soymida febrifuga root callus were tested for their phytochemical constituents and antimicrobial activity. Among them, ethyl acetate extract was found to be most effective, which on subjection to silica gel column chromatography led...

Four new flavone C-glycosides, luteolin 6-C-α-L-arabinopyranosyl-7-O-β-D-glucopyranoside, apigenin 6-C-β-D-galactopyranosiduronic acid (1 → 2)-α-L-arabinopyranoside, luteolin 6-C-β-D-galactopyranosiduronic acid (1 → 2)-α-L-arabinopyranoside, and luteolin 6-C-β-D-glucopyranosiduronic acid (1 → 2)-α-L-arabinofuranoside, along with three known ones, were isolated from the leaves of Lophatherum gra...