Abstract Severe acute respiratory syndrome coronavirus is a type 2 highly contagious, and transmissible among humans; the natural human immune response to severe syndrome-coronavirus-2 combines cell-mediated immunity (lymphocyte) antibody production. In present study, we analyzed dynamic effects of adaptive system cell activation in host. The methodology consisted modeling using ordinary differ...

The development of reliable assay systems that can measure lymphocyte activation in vitro has been a major goal of immunodiagnostics. Traditionally, tritiated thymidine incorporation has been used to monitor T-cell activation. Other methods include enzyme-linked immunosorbent assay (ELISA), enzyme-linked immunospot assay, and colorimetric assays. We have established a lymphocyte activation assa...

The capacity of retinole acid to modulate human T-lymphocyte and B-lymphocyte activation by mitogens was examined. Tlymphocyte proliferation stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA) or phytohemagglutinin was enhanced by 5 nw to 5 U.Mretinoic acid in a dose-dependent manner with a 65 ± 35% (SD) increase (n = 6, P < 0.01) in TPA-stimulated proliferation induced by 5 U.Mretinoic a...

The present studies have identified cloned Lyt-1+2- T suppressor (Ts) cells that are both antigen specific and major histocompatibility complex (MHC) restricted in their activation requirements and that function to regulate the MHC-restricted activation of B cells by T helper (Th) cells. ParentA-restricted Ts clones suppressed, in antigen-specific fashion, the responses generated by (A X B)F1 T...

Although a very large number of engineered defects in murine lymphocyte development have been generated in the last decade, naturally occurring disorders of lymphocyte development have (not too surprisingly!) been most thoroughly investigated in man. In this lecture the focus will primarily be on naturally occurring human immunodeficiencies that arise because of mutations in genes critical for ...

BACKGROUND Beside their established function in shaping cell architecture, some cell polarity proteins were proposed to participate to lymphocyte migration, homing, scanning, as well as activation following antigen receptor stimulation. Although PALS1 is a central component of the cell polarity network, its expression and function in lymphocytes remains unknown. Here we investigated whether PAL...

The symptoms of infectious mononucleosis (IM) are thought to be caused by T cell activation and cytokine production. Surface lymphocyte activation marker (SLAM)-associated protein (SAP) regulates lymphocyte activation via signals from cell-surface CD244 (2B4) and SLAM (CD150). We followed T cell activation via this SAP/SLAM/CD244 pathway in IM and analyzed whether the results were associated wi...

The macrophage has been implicated in the elaboration of a spectrum of molecules which alter or modulate the functions of hemopoietic and lymphoid cells. These include colony-stimulating factor (CSF),' required for the renewal and clonal proliferation of granulocyte-macrophage stem cells in semisolid culture (1), lymphocyte-activating factor which potentiates the mitogenic response of T lymphoc...

Background: Thermal burn injuries impair the host defence system. Hence, in the present study, we aimed at investigating the changes in the number and phenotype of peripheral blood lymphocyte populations (T, B, and natural killer cells) and their subpopulations in patients with thermal burns and determining the relationships with different sizes of total body surface area (TBSA). &nbsp;&nbsp; ...

Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder of the mononuclear phagocytic system, characterised by histiocyte and lymphocyte activation. It can be classified as primary secondary HLH. Primary HLH usually presents in childhood, associated with gene mutations. Secondary adulthood, due to an underlying infection, autoimmune disease or malignancy. We describe case acute hepatitis-A ...