Dose and time intensifications of chemotherapy improved the outcome of lymphoma therapy. However, recent study results show that too intense therapies can result in inferior tumour control. We hypothesise that the immune system plays a key role in controlling residual tumour cells after treatment. More intense therapies result in a stronger depletion of immune cells allowing an early re-growth ...

Köhler and Milstein, their use as a targeted therapy for cancer has been explored widely. Depending on antigen specificity, antibodies have the potential to react preferentially with tumor cells while binding to a lesser degree with normal tissues. This is in great contrast to chemotherapy (and to some degree radiotherapy), where significant toxicity results from drug exposure to various organs...

The stomach is the most frequent site of extranodal lymphoma. Gastric lymphoma originating from mucosa-associated lymphoid tissue (MALT) is typically a low-grade, B-cell neoplasia strongly associated with Helicobacter pylori (H. pylori) infection. Only certain H. pylori strains in some predisposed patients determine lymphoma development in the stomach, according to a strain-host-organ specific ...

In patients newly diagnosed with malignant lymphoma, examination of the bone marrow, along with the performance of routine laboratory testing, is among some of the tests needed to determine extent of disease prior to initiation of therapy. A bone marrow examination can also be performed in patients in whom a clinical suspicion of lymphoma is present, but cannot be confirmed due to nondiagnostic...

BACKGROUND Peripheral T-cell lymphomas (PTCL) are infrequent subtypes of non-Hodgkin's lymphomas. The clinical course is aggressive and the median survival is about 2-3 years. An optimal first-line chemotherapy protocol has not been established and the role of high-dose therapy with autologous stem cell transplantation (ASCT) is still unclear. AIM To analyze the long-term outcome of unselecte...

Fludarabine, a fluorinated analogue of adenine, was given to 11 patients with macroglobulinemic lymphoma, all but one having failed prior standard chemotherapy. Five patients (45%) responded with more than a 50% reduction of immunoglobulin M (IgM) tumor mass for a projected median duration of longer than 1 year. The onset of remission was usually slow, with a median tumor halving time of 5.2 mo...

A modern strategy for the treatment of diseases associated with Helicobacter pylori is mandatory inclusion in scheme antibiotics, as well considering level bacterial resistance to main components therapy. In Ukraine, infection some areas can reach about 80%, so prevalence peptic ulcer, atrophic gastritis and other gastrointestinal tract extremely high all sections population. Topical our countr...