l_Iany attempts have been made in the past to alter suggestibility by _s. Among the agents which have been employed have been ether _.4RK:EY 1917), nitrous oxide (E:_'SE,XCK 1945), barbiturates (Sc_[ILDER KAUDER 1927; t{ORSLEY 1943), scopolamine iBAERNSTE1-X 1929), al_hol (HvLL 1933), hyperventilation (COHEX and COBB 1939), phenothiazine derivatives (AL_]X_X.XI)ER1957; WEST 1956; SI)IKO 1963), ...

We raised high-titre antisera to two LSD-bovine serum albumin conjugates, one linked via the indole nitrogen, the other via the amide side-chain. The antisera were specific for different parts of the LSD molecule, as demonstrated by cross-reactivity studies with LSD, its metabolites, ergot alkoloids, and closely related compounds. The antisera were used to develop a double-antibody radioimmunoa...

A double-blind, randomized, active placebo-controlled pilot study was conducted to examine safety and efficacy of lysergic acid diethylamide (LSD)-assisted psychotherapy in 12 patients with anxiety associated with life-threatening diseases. Treatment included drug-free psychotherapy sessions supplemented by two LSD-assisted psychotherapy sessions 2 to 3 weeks apart. The participants received ei...

Although it is commonly stated that phencyclidine is an antagonist at ionotropic glutamate receptors, there has been little measure of its potency on other receptors in brain tissue. Although we previously reported that phencyclidine stimulated cloned-dopamine D2Long and D2Short receptors, others reported that phencyclidine did not stimulate D2 receptors in homogenates of rat brain striatum. Th...

d-Lysergic Acid Diethylamide (LSD) is known for its hallucinogenic properties and psychotic-like symptoms, especially at high doses. It is indeed used as a pharmacological model of psychosis in preclinical research. The goal of this review was to understand the mechanism of action of psychotic-like effects of LSD. We searched Pubmed, Web of Science, Scopus, Google Scholar and articles' referenc...

2005 2 Animum rege, qui nisi paret, imperat. distribution and neuronal localization of c-fos protein in the rat hippocampus following 4-aminopyridine seizures.competitive NMDA receptor antagonists moderate seizure-induced c-fos expression in the rat cerebral cortex. Z.: Alterations of seizure-induced c-fos expression in the rat cerebral cortex following dexamethasone treatment. (submitted) V.fo...

It is well established that repeated administration of both 5-hydroxytryptamine(2) (5-HT(2)) receptor agonists and antagonists decreases the density of 5-HT(2A) and 5-HT(2C) receptors. However, the regulation of these two receptors has not been studied in the same tissue. Therefore, we examined the effects of repeated daily injections of the 5-HT(2) receptor agonists (+/-)-2,5-dimethoxy-4-iodoa...

1. The effect of lysergic acid diethylamid (LSD) on the response to field stimulation in vitro of the rat vas deferens and anococcygeus muscle was examined. 2. LSD in concentrations from 10(-9) to 10(-6) M caused an increase in tone or rhythmic activity in both tissues, effects identical to those produced by guanethidine or tyramine. The motor effects of all three drugs were abolished by phento...

Roughly over 700 million individuals suffer from a mental illness globally. In the United States alone, 45 are afflicted with disorder at any given point in their lives. It is because of this that new methods current therapies should be considered. To date, major depression (MAD), anxiety, and post-traumatic stress (PTSD) treated Selective Serotonin Reuptake Inhibitors (SSRIs). While treatment ...