The Cs symmetric methylgermyl radical, H2GeCH3(X A0), and its D5-isotopomer were detected via infrared spectroscopy in electron-irradiated methane – germane matrices via the m6 mode at 839 cm 1 and the m12 absorption at 1406 cm . ExperimentswithD4-germane –D4-methanematrices also detected absorptions from theD5-methylgermyl species upon electron exposure at 624 cm 1 (m7) and 1406 cm 1 (m3) orig...

A conic of the Veronese surface in PG(5, 3) is a quadrangle. If one such quadrangle is replaced with its diagonal triangle, then one obtains a point model K for Witt’s 5–(12, 6, 1) design, the blocks being the hyperplane sections containing more than three (actually six) points of K. As such a point model is projectively unique, the present construction yields an easy coordinate–free approach t...

Conventional wisdom suggests that an increase in monetary incentives should induce agents to exert higher effort. In this paper, however, we demonstrate that this may not hold in team settings. In the context of sequential team production with positive externalities between agents, incentive reversal might occur: an increase in monetary incentives (either because rewards increase or effort cost...

Distorted performance measures in compensation contracts elicit suboptimal behavioral responses that may even prove to be dysfunctional (gaming). This paper applies the empirical test developed by Courty and Marschke (2008) to detect whether the widely used class of Residual Income based performance measures —such as Economic Value Added (EVA)— is distorted, leading to unintended agent behavior...

OBJECTIVE Anti-synthetase syndrome (anti-SS) is frequently associated with myositis and interstitial lung disease (ILD). We evaluated prospectively, in a multicenter, open-label, phase II study, the efficacy of rituximab on muscle and lung outcomes. METHODS Patients were enrolled if they were refractory to conventional treatments (prednisone and at least 2 immunosuppressants). They received 1...

Loss of mismatch repair (MMR) function leads to the accumulation of errors that normally occur during DNA replication, resulting in genetic instability. Germ-line mutations of MMR genes in the patients with hereditary nonpolyposis colorectal cancer lead to inactivation of MMR protein functions, and the defects of MMR are well correlated to the high rate of microsatellite instability in their tu...

The class II major histocompatibility complex molecule I-A(g7) is strongly linked to the development of spontaneous insulin-dependent diabetes mellitus (IDDM) in non obese diabetic mice and to the induction of experimental allergic encephalomyelitis in Biozzi AB/H mice. Structurally, it resembles the HLA-DQ molecules associated with human IDDM, in having a non-Asp residue at position 57 in its ...

Absorption, metabolism, and excretion of paliperidone, an atypical antipsychotic, was studied in five healthy male subjects after a single dose of 1 mg of [(14)C]paliperidone oral solution ( approximately 16 microCi/subject). One week after dosing, 88.4 to 93.8% (mean 91.1%) of the administered radioactivity was excreted: 77.1 to 87.1% (mean 79.6%) in urine and 6.8 to 14.4% (mean 11.4%) in the ...

Abstract Introduction Transthyretin–mediated (ATTR) amyloidosis is a progressive and fatal disease. Patients with hereditary or wild–type ATTR frequently develop cardiomyopathy (CM). Patisiran, an IV RNAi therapeutic that inhibits synthesis of wt variant TTR, approved for the treatment hATTR polyneuropathy. Methods In APOLLO–B, patients were 18–85 yrs old evidence cardiac by echocardiography, a...

In this paper we derive rates of strong convergence for the kernel density estimator and for the Nadaraya-Watson estimator under the-mixing condition and under the condition of absolute regularity. A combination of an inequality of Bernstein type (Rio 1995) and an exponential inequality (cf. Fuk/Nagaev 1971) is the crucial tool for the proofs. Moreover, we consider the application of the main s...