The title compound, [Ni(C(40)H(28)N(4)O)], was obtained from a Grignard reaction of the respective formyl-porphyrin to yield {5-[hy-droxy(phen-yl)meth-yl]-10,20-diphenyl-porphyrinato}nickel(II), followed by crystallization from methyl-ene chloride/methanol. The mol-ecule exhibits a ruffled macrocycle with an average deviation of the 24 macrocycle atoms from their least-squares plane (Δ24) of 0....

Macrocyclic compounds have potential to enable drug discovery for protein targets with extended, solvent-exposed binding sites. Crystallographic structures of peptides bound at such sites show strong surface complementarity and frequent aromatic side-chain contacts. In an effort to capture these features in stabilized small molecules, we describe a method to convert linear peptides into constra...

Three new chiral Mn macrocycle catalysts containing 20 or 40 atoms in the were synthetized and tested enantioselective epoxidation of cis-β-ethyl-styrene 1,2-dihydronathalene. The effect presence a binaphtol (BINOL) compound catalyst backbone has been evaluated, including by Density Functional Theory (DFT) calculations.

The effect of different pendant arms on the structural chemistry 1,4,7-trithia-10-aza-cyclododecane ([12]aneNS3) macrocycle is discussed in relation to coordination all known functionalized derivatives [12]aneNS3, which have been structurally characterized.

Out-of-plane deformations of metalloporphyrin skeletons have been well documented as playing important roles in relevant biological processes. In contrast, out-of-plane binding to the N-core large metal cations period 6 post-transition elements has remained poorly investigated. We describe herein monometallic complexes Pb(II) and Bi(III) with 5,10 single strapped porphyrin ligands bearing a car...