autoimmune diseases have been described as an interesting and poorly understood group of disorders. there are many challenges in the respective scientific societies concerning the nature, causes and the therapeutic approaches of these diseases. in accordance with the evidences the nature and etiology of these disorders is multifactorial and complex but the clearest definition could be expressed...

introduction: the field of stem cell biology and regenerative medicine is rapidly moving toward translation to clinical practice. stem cell therapy seems to be a new treatment option for some diseases. so, tracking the distribution of stem cells is crucial to their therapeutic use. based on this fact we labeled human mesenchymal stem cells (mscs) with 111in- oxine for the first time in our coun...

mobile phone use and wireless communication technology have grown explosively over the past decades. this rapid growth has caused widespread global concern about the potential detrimental effects of this technology on human health. stem cells generate specialized cell types of the tissue in which they reside through normal differentiation pathways. considering the undeniable importance of stem ...

objective: this study presents an efficient, cost-effective method to improve proliferation and colonization of spermatogonial stem cells (sscs) in vitro. methods: isolated sscs from neonate mice were cultured in dmem culture medium with 10% fetal bovine serum (fbs). in the first phase of the study, the temperature was controlled by low intensity pulsed ultrasound stimulation (lipus) of the pla...

Stem cells and their descendents are the building blocks of life. How stem cell populations guarantee their maintenance and/or self-renewal, and how individual stem cells decide to transit from one cell stage to another to generate different cell types are long-standing and fascinating questions in the field. Here, we review the discussions that took place at a recent EMBO conference in Cambrid...

Glioblastoma is a destructive form of brain tumor that kills most patients within two years of diagnosis.Treatments for glioblastoma include the usual options of surgery, radiation therapy and chemotherapy, but there is no effective treatment. The tumors are capable of spreading tendrils out into the brain and it can grow back in a matter of months after being removed. The cancer stem cell...

Stem cells are regulated both intrinsically and externally, including by signals from the local environment and distant organs. To identify genes and pathways that regulate stem-cell fates in the whole organism, we perform a genome-wide transgenic RNAi screen through ubiquitous gene knockdowns, focusing on regulators of adult Drosophila testis germline stem cells (GSCs). Here we identify 530 ge...

Overexpression of the polycomb group protein enhancer of zeste homologue 2 (EZH2) occurs in diverse malignancies, including prostate cancer, breast cancer, and glioblastoma multiforme (GBM). Based on its ability to modulate transcription of key genes implicated in cell cycle control, DNA repair, and cell differentiation, EZH2 is believed to play a crucial role in tissue-specific stem cell maint...

Owing to their location at the interface with external environment, stem cells of epidermis are particularly exposed environmental variations such as fluctuating temperature. However, little is known about how temperature affects epidermal cell metabolism and behavior. Here we demonstrate that cultured human (HESCs) respond a small drop in through thermos-sensitive TRP channels connected mTOR s...