abstract objective cardiac dysfunction is a major cause of death in patients with beta thalassemia. in these patients, repeated blood transfusion, ineffective erythropoiesis and increased gastrointestinal iron absorption lead to iron overload in the body and this induced heart failure. left ventricular ejection fraction was measured in major beta thalassemia (β-th) patients to detect the relati...

in order to identify left ventricular diastolic function in patients with betathalassemia major and normal systolic function by noninvasive m-mode and doppler echocardiography, an analytic study was designed in a university hospital in sari. we have studied 44 patients (23 men and 21 women), mean age 15.48±2.16 (range 12 to 20) and 43 age and sex matched control subjects. peak flow velocity in ...

background: expansion of bone marrow cavity and decreased cortical and trabecular bone tissues and osteoporosis are resulted from beta-thalassemia. the aim of this study was to assess bone mineral density (bmd) in patients with β thalassemia major and intermedia, and to determine their biochemical and hormonal profiles that may affect bmd. materials and methods: in a cross sectional study from ...

background: advances in treatment of thalassemia major have improved the life expectancy of the patients and therefore their quality of life as other chronic diseases. this study was conducted to assess health- related quality of life in these patients in guilan province. methods: in a cross-sectional study, thirty-one children, aged 8-12 years, with β-thalassemia major were interviewed in guil...

Alzheimer’s disease (AD) is a neuroinflammatory based pathologic state in which β-amyloid aggregates are a major devastating agents. In this study, a series of 2-hydroxyiminoethanones were synthesized and evaluated as anti-inflammatory in carrageenan and formalin tests and inhibitors of β-amyloid aggregation. Compounds 1-10b were synthesized through a two-step reaction. Results: Compounds 1-5b ...

Sarcopenia is characterized by two major phenotypic components: low handgrip strength (HGS) and appendicular lean mass index (ASMI). Oral corticosteroid (OCS) use an important medication for acute respiratory exacerbations in patients with COPD asthma. However, the association of OCS sarcopenia components older people are largely unexplored. To examine between HGS or ASMI general population exp...

medicinal plante borazambol with the scientific name of perovskia abrotanoides karel. belongs to the family lamiaceae. it is growing wild in the margin of mountainous roads of arid and cold climate of north iran. it is for a long time that indigenous people by different methods in traditional medicine use its products in preventing and curing diseases. in this research, essential oils of perovs...

abstract background prevention of myocardial siderosis is a key step to reduce rate of mortality in thalassemic patients. our objective was to study association between echocardiography parameters and serum ferritin level in patients with major thalassemia. materials and methods sixty-six patients with major thalassemia were studied in amir kabir hospital, arak, iran. serum ferritin levels were...