Mastocytosis can be associated with other clonal or non-clonal hematologic diseases as well as a variety of non-hematologic malignancies. A 75-year-old Caucasian male patient was referred to us with a 5-month history of neutrophilic leukocytosis and mild splenomegaly. He had developed a cutaneous melanoma sixteen years ago. According to the clinical and pathological features, a final diagnosis ...

The transforming growth factor(TGF) signaling pathway is an essential regulator of cellular processes, including proliferation, differentiation, migration, and cell survival. During hematopoiesis, the TGFsignaling pathway is a potent negative regulator of proliferation while stimulating differentiation and apoptosis when appropriate. In hematologic malignancies, including leukemias, myeloprolif...

Adolescents and young adults (AYA) with cancer have been designated as a vulnerable population by the National Cancer Institute. This group, defined by the ages of 16-39 years, has not enjoyed the same survival improvements over the past several decades as older and younger cohorts. Several barriers prevent the optimal delivery of oncologic care in this subpopulation. This review will describe ...

background and objectives: we aimed at evaluating the efficacy of fine needle aspiration biopsy (fna) in comparison with histopathology and demonstrating whether cytological study could be a proper diagnostic tool in orbital mass lesions. materials and methods: in a cross sectional study during 36 months, patients referred to our ophthalmologic center affiliated to tehran university of medical ...

BACKGROUND AND PURPOSE The purpose of this study was to evaluate the mortality rates associated with cerebral venous-sinus thrombosis in a large national sample. METHODS A cohort of patients with cerebral venous-sinus thrombosis was identified from the National Inpatient Sample database for the years 2000 to 2007. According to the International Classification of Diseases, 9th Revision, Clinic...

we present a woman referred with underlying non-hodgkin's lymphoma (nhl) masquerading clinically with guillain-barré syndrome (gbs) like syndrome. at first evaluation, chest ct-scan along with brain and whole spine mri were normal. electrodiagnostic studies were in favor of acute generalized polyradiculoneuropathy. laboratory evaluation revealed hypoglycorrhachia. she treated with plasmapheresi...

BACKGROUND Stroke and sleep-related breathing disorders are both common and are associated with significant morbidity and mortality. Several recent large epidemiological studies have shown a strong association between these 2 disorders independent of known risk factors for stroke. This article will outline the scientific basis for this relationship and suggest sleep-related breathing disorders ...

Objective Myeloblasts are rarely found in the composition of a chronic subdural hematoma (CSH), and reported cases with myeloblasts in CSH have all been associated with systemic hematologic disorders. We present a young man with CSH manifesting the diffuse presence of myeloblasts, although no systemic hematologic disorders were identified. Participant A 27-year-old man, complaining of a headach...

Neurologic changes can be seen during treatment for hematologic malignancies such as lymphoma and leukemia. Differential diagnoses for neurologic changes remain vast, and etiologies may result from malignant, nonmalignant, and paraneoplastic syndromes. This article describes a case study of a man with neurolymphomatosis, a rare neurologic manifestation seen in B-cell and non-Hodgkin lymphoma an...