The porphyrias are a group of disorders of heme metabolism that result from partial defects in the several enzymes that control heme biosynthesis. Accumulation of porphyrins or porphyrin precursors in several different patterns results from these defects and biochemically characterizes each specific syndrome. Patterns of cutaneous photosensitivity and associated systemic symptoms among the seve...

Coproporphyrin and uroporphyrin are separated from urineand from each other by absorption onto, and Selective elution from, an anion-exchange resin. The two compounds are #{233}eparated by using solvents differing in both polarity and pH. The porphyrins are then quantitated with an Aminco-Bowman Spectrophotofluorometer equipped with an ellipsoidal mirror and a red-sensitive photomultiplier tube...

A reversed-phase h.p.l.c. system is described for the separation of all five naturally occurring pentacarboxylic porphyrinogen isomers. The compounds are detected electrochemically with high sensitivity. The peaks are positively identified by h.p.l.c. analysis of the pentacarboxylic porphyrinogens from reduction of pentacarboxylic porphyrins prepared by partial decarboxylation of hexa- and hept...

The use of halogens in the crystal engineering supramolecular porphyrin assemblies has been a topic strong interest over past decades. With this mind we have characterized series direct meso-halogenated porphyrins using single X-ray crystallography. This is accompanied by detailed conformational analysis all deposited CSD. In study used Hirshfeld fingerprint plots together with normal-coordinat...

Furan-2,5-diylbis(phenylmethanol) is a key intermediate to access sub(oxa)porphyrins. Previously, this was accessible from fossil-derived furan using highly dangerous lithium reagents. Presently, we have produced cashew apple bagasse (CAB), via the formation of 5-hydroxymethylfurfural (HMF). CAB non-food biomass containing cellulose and hemicellulose. From CAB, obtained HMF in yield 310 mg/g CA...

A series of six Zn(II) tetraphenylporphyrins (ZnTPP), with a phenyl (P) or oligophenyleneethynylene (OPE = (PE) n ) rigid-rod bridge varying in length (9-30 A) and terminated with an isophthalic acid (Ipa) anchoring unit, were prepared as model dyes for the study of sensitization processes on metal oxide semiconductor nanoparticle surfaces (MO(n) = TiO(2), ZnO, and insulating ZrO(2)). The dyes ...

Manganese-deficient individuals have decreased manganese elimination. This observation has prompted suggestions that relative manganese deficiency may increase the risk for manganese neurotoxicity following inhalation exposure. The objective of this study was to determine whether dietary manganese intake influences the pharmacokinetics of inhaled manganese tetroxide (Mn3O4). Postnatal day (PND)...

We employed Circular Dichroism (CD) and UV/Vis-spectrophotometric methods to study the interaction of two Fe-containg cationic porphyrins: meso-tetra (4N-butylpyridyl) porphyrin [FeTButPyP4] and meso-tetra (4N-oxyethylpyridyl) porphyrin [FeTOEtPyP4] with DNA at various ionic strengths. The temperature-dependent absorption titration data were used to determine the binding constants and stoichiom...