The aim was to study cytogenetic changes in bone marrow cells of laboratory animals that received and did not receive a genetically modified (GM) product (GM-soy) comparative aspect. It found the group white outbred rats GM-soy, were red marrow, expressed partial inhibition cell proliferation due cytotoxic effect. They also had polyploidy (5.35%) aneuploidy 10.7% cases. In addition, this contai...

essential thrombocythemia is a rare myeloproliferative disorder in pediatrics. this myeloproliferative disorder is charactherized by thrombocytosis and hyperplasia of megakaryocytes in the bone marrow. other cell lines are not involved.jak2v617fmutations has been identified in approximately half the patients with this disorder. we describe a 12-year-old boy with essential throbocythemia. the pa...

hemophagocytic syndrome is a non-malignant process that is characterized clinically by fever, hepatomegaly, splenomegaly, pancytopenia in peripheral blood, and reactive histiocytes in the bone marrow. bacterial infectious diseases like typhoid fever and brucellosis and viral infections including cmv, herpes viruses, and epstein-barr virus are diagnosed as the cause of this syndrome. in this pap...

Provision of colony-stimulating activity (CSA) by human marrow cells was determined utilizing culture techniques in vitro to assess intramedullary cellular interactions on human granulopoiesis. CSA production from marrow cells of 21 patients with acute myeloid leukemia (AML) was evaluated and compared to normal marrow by testing the capacity of conditioned media from adherent marrow cells to pr...

BACKGROUND Treatment of many inherited liver enzyme deficiencies requires the removal of toxic intermediate metabolites from the blood of affected individuals. We propose that circulating toxins can be adequately cleared and disease phenotype influenced by enzyme expressed in tissues other than the liver, such as bone marrow. Our specific hypothesis was that phenylalanine hydroxylase (PAH) expr...

Myelofibrosis (MF) is a rare disorder that classified as one of the myeloproliferative disorders. It BCR-ABL1- negative neoplasm characterized by abnormal proliferation hemopoietic stem cells within bone marrow, which leads to overproduction fibrous tissue. Our patient young girl 17 year old presented with lump in left upper abdomen, shortness breath & generalized swelling. The diagnosis wa...