Brain-Derived Neurotrophic Factor and Maternal Behavior: Neuronal Alterations in the Medial Preoptic Area and Suppression of Pup Attacks Lillian Flores Stevens Master of Arts in Psychology, 2003 University of Richmond Thesis Director: Dr. Craig H. Kinsley Brain-derived neurotrophic factor (BDNF), by virtue of its relationship to various neurotransmitter systems, hormones, and to estrogen in par...

Cross-fostering studies in the rat have illustrated the importance of the postnatal environment in mediating the transmission of maternal licking/grooming (LG) from mother to offspring. The authors addressed the question of how postweaning social conditions can alter the patterns of maternal behavior. Juvenile female offspring of high LG and low LG mothers were placed in either standard, enrich...

Endocrine disruption during gestation impairs the physical and behavioral development of offspring. However, it is unclear whether endocrine disruption also impairs maternal behavior and in turn further contributes to the developmental and behavioral dysfunction of offspring. We orally administered the synthetic non-steroidal estrogen diethylstilbestrol (DES) to pregnant female C57BL/6J mice fr...

Maternal behavior is probably the most important pro-social behavior in female mammals, ensuring both the development and survival of her offspring. Signals driving maternal behaviors are complex and involve several brain areas, most of which are innervated by serotonin. Serotonin transmission influences maternal processes indirectly through release of maternally-relevant hormones such as prola...

The neuropeptide oxytocin (OT) acts on a widespread network of brain regions to regulate numerous behavioral adaptations during the postpartum period including maternal care, maternal aggression, and anxiety. In the present study, we examined whether this network also includes the medial prefrontal cortex (mPFC). We found that bilateral infusion of a highly specific oxytocin receptor antagonist...

The study aimed at investigating the impact of children temperament, maternal responsiveness and maternal childrearing practices on children externalizing behavior problems and social competence. The study involved 23 child-mother dyads from different socio-economical backgrounds. In the baby’s third month after birth, child temperament and maternal responsiveness were evaluated. In the child’s...

OBJECTIVE Maternal maltreatment history and current parenting stress are associated with parenting difficulties. However, researchers have not investigated the mechanism by which these variables are interlinked. We hypothesized that parenting stress mediates the relation between history of maltreatment and parenting behavior. METHODS We assessed a community sample of 291 mothers as they inter...

This study tested predictions from economic and developmental theories that maternal time with an infant is important for mother-child relationships and children's development, using time-use diaries for mothers of 7- to 8-month-old infants from the National Institute of Child Health and Human Development Study of Early Child Care (N = 1,053). Employment reduced time with infants, but mothers c...

BACKGROUND Prenatal cocaine exposure is a marker of developmental risk. Social environmental risk factors may include maternal stress and maternal perceptions of difficult infant temperament. OBJECTIVES To examine factors that may predict or moderate maternal ratings of parenting stress and difficult temperament in cocaine-exposed (CE) infants. METHOD Neonatal behavior, infant temperament, ...