Thyroid dysfunctions such as hypothyroidism, thyrotoxicosis and thyroid nodules may develop during pregnancy leading to abortion, placental abruptions, preeclampsia, preterm delivery and reduced intellectual function in the offspring. Epidemiological data have shown the significant role of maternal thyroid hormone in fetal neurologic development and maternal health. It has been suggested that t...

OBJECTIVE We describe an infant with surprisingly severe neonatal hypothyroidism due to transplacental passage of thyrotrophin receptor (TSH-R)-blocking antibodies (TBAb). DESIGN AND METHODS TBAb were detected using a cell line which stably expresses the human TSH-R and a cAMP-responsive luciferase reporter by their ability to inhibit TSH-stimulated luciferase expression. Potent TBAb were det...

CONTEXT Screening programs not only offer the opportunity to trace and treat almost all cases of congenital hypothyroidism but also mean large savings to the health system. However, carefully planned strategies are necessary to extend their benefits and reduce costs. OBJECTIVE To determine the possible influence of maternal diseases that affect maternal-fetal placenta dynamics on primary thyr...

BACKGROUND The effects of maternal subclinical hypothyroidism (M-SCH) on the neuropsychological development of the offspring are not clear. We evaluated the intellectual development of children of mothers who had M-SCH during the pregnancy for these children. METHODS Sixty-two children were recruited. After excluding those age < 4 or age > 15, 44 were enrolled. The mothers of these children w...

To determine whether developmental hypothyroidism causes permanent disruption of neuronal development, we first performed a global gene expression profiling study targeting hippocampal CA1 neurons in male rats at the end of maternal exposure to anti-thyroid agents on weaning (postnatal day 20). As a result, genes associated with nervous system development, zinc ion binding, apoptosis and cell a...

BACKGROUND The aim of this study was to investigate the relationship between congenital hypothyroidism and several variables using two different adjustment methods. METHODS This matched case-control study was conducted in Hamadan Province, the west of Iran, in 2012 enrolling neonates born between 2005 and 2011 and covered by screening program for congenital hypothyroidism. The neonates with T...

Perchlorate ion interferes with thyroid function by competitively inhibiting the sodium-iodide symporter, thus blocking iodide uptake into the thyroid gland. In this study, the effect of perchlorate exposure on thyroid function and thyroid-responsive gene expression were examined in (1) embryos from eggs laid by perchlorate-treated Japanese quail hens and (2) perchlorate-treated young Japanese ...

Fetal goiter is an uncommon, serious problem during pregnancy. Careful routine antenatal ultrasound screening can find out an intrauterine fetal goiter. Fetal goiter has an incidence of 1:40000 live births (1). 80% of cases are caused by dysgenesis of the thyroid gland. The rest 5% and 15% are due to hypothalamohypophyseal abnormalities and dyshormonogenesis, respectively. 8% of cases are due t...

how to cite this article: mirouliaie m, fallah r, partovee m, ordooei m. efficacy of levothyroxine in migraine headaches in children with subclinical hypothyroidism. iran j child neurol autumn 2012;6(4):23-26.   abstract objective hypothyroidism may be an exacerbating factor for  primary headaches and migraine is one of the most common primary headaches in childhood. thepurpose of this study wa...