Polysaccharide mucilage derived from the seeds of Ocimum basilicum L. (family Lamiaceae) was investigated for use in matrix formulations containing propranolol hydrochloride. Basil mucilage was extracted and several tablets were formulated. The effect of mucilage on drug release rate was evaluated in comparison with tablets containing two kinds of hydroxypropyl methylcellulose (HPMC K4M and HPM...

Three-dimensional printing (3DP) is a unique prototyping technology that has advanced over the past 35 years and has the great potential to revolutionize the field of drug delivery with its inherent advantages of customizability and the ability to fabricate complex solid dosage forms with high accuracy and precision. 3DP can fabricate solid dosage forms with variable densities and diffusivities...

The objective of the present study was to evaluate the effect of sintering condition on matrix formation and subsequent drug release from polymer matrix tablet for controlled release. The present study highlights the use of a microwave oven for the sintering process in order to achieve more uniform heat distribution with reduction in time required for sintering. We could achieve effective sinte...

The purpose of this paper is to apply TRIZ for solving the GSC problems in Sobhanoncology pharmaceutical firm. A review of the past papers of TRIZ based methods to GSC problem resolution is presented. The TRIZ contradiction matrix tool which was applied to the specific problem brings many benefits e.g.: being rapid acceleration in solving the problem. Moreover provides repeatability, reliabilit...

The matrix tablets were prepared by using Eudragit L 100, Poly ethylene oxide and Carbopol 971 P. The granules of Zidovudine using above polymers were prepared by direct mixing, wet granulation with water and wet granulation with IPA. The granules were characterized for the morphological study, bulk density, tapped density and particle size distribution. The granules were compressed in to table...

A conventional preoxygenation technique was compared in two volunteers with two techniques based on a drawover breathing system supplied with oxygen enriched air from a Devilbiss Mini VO2 domiciliary oxygen concentrator. Breathing from a 20-litre bag, filled previously at 2 litre min-1 from the concentrator was as effective as the conventional technique (PaO2 73.2 kPa). Supplying 4 litre min-1 ...

The objective of the present study was to develop once-daily sustained-release matrix tablets of naproxen, one of the most potent non-steroidal anti-inflammatory agents used in the treatment of arthritic pain. The tablets were prepared by direct compression method using hydrophilic matrix materials like Methocel K4M CR and Methocel K15M CR. The tablets were subjected to measurement of thickness...

A capsule is a group of neurons whose outputs represent different properties of the same entity. Each layer in a capsule network contains many capsules. We describe a version of capsules in which each capsule has a logistic unit to represent the presence of an entity and a 4x4 matrix which could learn to represent the relationship between that entity and the viewer (the pose). A capsule in one ...