Polycyclic aromatic hydrocarbons (PAHs) are very toxic and persistent environmental micro-contaminants that possess health-impacting tendencies. Environmental levels of PAHs mainly exacerbated by anthropogenic activities. At elevated concentrations, become readily bio-magnify across the food chain. This study was undertaken to determine concentration identify possible sources in Imiringi River....

BACKGROUND The medial collateral ligament (MCL) is the most frequently injured ligament of the knee, but it infrequently requires surgical treatment. Current literature on MCL reconstructions is sparse and offers mixed outcome measures. PURPOSE/HYPOTHESIS The purpose of this study was to compare the outcomes of isolated MCL reconstruction and multiligamentous MCL reconstruction. Our hypothesi...

BACKGROUND We previously showed that B-cell receptor (BCR) signaling pathways are important for in vitro survival of mantle cell lymphoma (MCL) cells. To further identify early BCR-activated signaling pathways involved in MCL cell survival, we focused our study on BCR-proximal kinases such as LYN whose dysregulations could contribute to the aggressive course of MCL. METHODS Primary MCL cells ...

PURPOSE In patients treated with allogeneic stem cell transplantation for advanced mantle cell lymphoma (MCL), complete sustained remissions have been observed illustrating susceptibility of MCL cells to a graft-versus-lymphoma effect. To potentiate this graft-versus-lymphoma effect, adoptive transfer of in vitro selected MCL-specific CTL can be an attractive approach. The lack of expression of...

MCL-1 (myeloid cell leukemia-1) is an antiapoptotic BCL-2 family protein discovered as an early induction gene during myeloblastic leukemia cell differentiation. This survival protein has the BCL-2 homology (BH) domains 1, 2, and 3 and a C-terminal transmembrane region. We identified a short splicing variant of the MCL-1 mRNA in the human placenta encoding a protein, termed MCL-1 short (MCL-1S)...

BACKGROUND Aim of the study was to investigate whether menstrual cycle length may be considered as a surrogate measure of reproductive health, improving the accuracy of biochemical/sonographical ovarian reserve test in estimating the reproductive chances of women referred to ART. METHODS A retrospective-observational-study in Padua' public tertiary level Centre was conducted. A total of 455 n...

BACKGROUND Mantle cell lymphoma (MCL) is an aggressive and incurable form of non-Hodgkin's lymphoma. Despite initial intense chemotherapy, up to 50% of cases of MCL relapse often in a chemoresistant form. We hypothesized that the recently identified MCL-initiating cells (MCL-ICs) are the main reason for relapse and chemoresistance of MCL. Cancer stem cell-related pathways such as Wnt could be r...

Greenhouse gas (GHG) emissions from municipal solid waste (MSW) management significantly contribute to high global warming potential (GWP). However, most studies have failed to facilitate identifying MSW management schemes capable of comprehensively meeting the goals from decision-makers at different hierarchical levels under uncertainties. This study develops an inexact bi-level linear program...

A comparison of adsorption efficiency of the three Granular Activated Carbon (GAC) produced from waste Nigerian Bamboo at different level of activation in a fixed adsorption bed is reported. Bamboo carbonization was done at temperature range of 200-400c and chemically activated at 400c with chloride salt at percentage range of 0-20%. The 0, 10 and 20% level activation were selected for water tr...