We present a computing framework for Monte Carlo simulation of radiation transport. In conformity with our belief that Monte Carlo studies should be anchored to physics but not to any particular code, we have enabled different Monte Carlo codes in this environment. The framework embraces the EGSnrc family, FLUKA, MCNP/MCNPX, GEANT4 and PENELOPE; dedicated and non-dedicated resources; shared and...

Inhibition of acetylcholinesterase and butyrylcholinesterase (AChE and BuChE) as two major forms of cholinesterases (ChEs) is considered as the common approach for the treatment of Alzheimer's disease (AD). The present study was done to explore the anticholinesterase inhibition property of coumarin Mannich base derivatives. A series of cumarin Manich bases were synthesized (4a-h) through one-po...

A non destructive technique based on gamma spectrometry and application of the Monte Carlo method for detector efficiency calibration, was used to assay radioactive content waste drums. Exploranium GR-130 miniSPEC portable gamma ray spectrometer was used to externally monitor radioactive waste drums containing ion exchange resin waste from the water demineralization system of GRR-1 open pool-ty...

Ionizing radiation effectively reduces the number of common microbial pathogens in fresh produce. However, the efficacy of the process for pathogens internalized into produce tissue is unknown. The objective of this study was to understand gamma irradiation of lettuce leaf structure exposed in a Cs irradiator using MCNP. The simulated Cs irradiator is a self-shielded device, and its geometry an...

Underwater vehicle is designed to ensure the security of country sea boundary, providing harsh requirements for its power system design. Conventional power sources, such as battery and Stirling engine, are featured with low power and short lifetime. Micronuclear reactor power source featured with higher power density and longer lifetime would strongly meet the demands of unmanned underwater veh...

This paper describes the mathematical efficiency calibration of the whole-body counter at Forschungszentrum Jülich using Monte Carlo codes and mathematical anthropomorphic phantoms. As a prerequisite for the Monte Carlo simulations a precise model of the 4 high-purity germanium (HPGe) detectors had to be developed. Because the technical data provided by the manufacturer were not sufficient for ...

Boron-neutron capture therapy (BNCT) is an experimental radiation treatment modality used for highly malignant tumor treatments. Prior to irradiation with low energetic neutrons, a B compound is located selectively in the tumor cells. The effect of the treatment is based on the high LET radiation released in the B(n,α)Li reaction with thermal neutrons. BNCT has been used experimentally for brai...

The accurate and efficient simulation of coupled neutron-photon problems is necessary for several important radiation detection applications. Examples include the detection of nuclear threats concealed in cargo containers and prompt gamma neutron activation analysis for nondestructive determination of elemental composition of unknown samples. In these applications, highresolution gamma-ray spec...

Rapid emergence of drug resistance in Mycobacterium tuberculosis (MTB) is a major health concern and demands the development of novel adjunct immunotherapeutic agents capable of modulating the host immune responses in order to control the pathogen. In the present study, we sought to investigate the immunomodulatory effects of G1-4A, a polysaccharide derived from the Indian medicinal plant Tinos...