Acute coadministrations of an inhibitor of endopeptidase 24.11 (thiorphan) and a ligand (SC-46542) selective for the non-guanylate cyclase-linked atriopeptin binding sites increases urinary sodium excretion to a greater degree in conscious spontaneously hypertensive rats than in normotensive Wistar-Kyoto rats. In the present study, we examined the effects of chronic 10-day intravenous infusions...

• In several investigations in the past, Wetterer and Pieper connected a sinusoidal piston pump to the arterial system of intact anesthetized dogs in order to produce slow oscillations of the mean arterial pressure upon which the arterial pressure pulsation was superimposed. Simultaneous measurements of various parameters permitted the calculation of the elasticity coefficient of the arterial r...

COX, ROBERT H. Pressure dependence of the mechanical properties of arteries in vivo. Am. J. Physiol. 229(5): 13714375. 1975.-Simultaneously measurements of intra-arterial pressure and external diameter were recorded from the thoracic and abdominal aortas, the carotid, brachiocephalic, left subclavian, and femoral arteries of anesthetized dogs. Data were recorded under control conditions and dur...

The effect of chronic renovascular hypertension on the autoregulation of cerebral blood flow was studied in anesthetized baboons. Cerebral blood flow was measured by the intracarotid 133Xe clearance method. Six baboons with renal hypertension of 8-12 weeks' duration were compared with six normotensive controls. The lower limit of autoregulation was determined following controlled hemorrhage. In...

conclusions blood glucose and hemodynamic changes caused by surgical stress were not significantly different between two groups. results there was not significantly difference between blood glucose level of both groups during 10 minutes before, 20 and 60 minutes after the intiation of anesthesia. heart rate changes in the general and spinal groups compared to the baseline level were decreased u...

Apelin is an endogenous depressor peptide for the G protein-coupled APJ receptor. Our hypothesis is that apelin is a venodilator, and it reduces mean circulatory filling pressure (MCFP; index of venous tone). Dose-response curves of apelin (10, 20 and 40 nmol/kg) or vehicle (0.9% NaCl) were constructed in two groups each of conscious, unrestrained rats: unblocked rats and rats pretreated with m...

Objectives To test the usefulness of continuous assessment of arterial load based on a 3-element Windkessel model by a combined analysis of the esophageal Doppler derived-blood flow and arterial pressure waveform, against standard frequency-domain analysis of arterial impedance. Methods Time-domain variables of arterial impedance were obtained by the simultaneous analysis of the Doppler derived...

1. The reflex control of renin release was studied in subjects with essential hypertension by com­ paring the effects of a variable-pressure neck chamber and head-up tilting. 2. Increase in carotid sinus transmural pressure (obtained by reducing tissue pressure outside the carotid sinus by 34 ± 3 mmHg) decreased mean arterial pressure by 16 + 2 mmHg, but did not reduce significantly the renal v...

BACKGROUND Arterial stiffness and mean arterial pressure variably contribute to systolic hypertension and increased cardiovascular risk. However, few prior community-based studies have evaluated the genetics of arterial stiffness and separate mean and pulsatile components of blood pressure. METHODS AND RESULTS Using arterial tonometry, we evaluated heritability and linkage of forward and refl...