OBJECTIVE Secretory phospholipase A2 (sPLA2) enzymes hydrolyze the sn-2 fatty acyl ester bond of phospholipids to produce a free fatty acid and a lysophospholid. Group V sPLA2 is expressed in cultured macrophage cells and has high affinity for phosphatidyl choline-containing substrates. The present study assesses the presence of group V sPLA2 in human and mouse atherosclerotic lesions and its a...

The molecular basis of the heterogeneity of plasma low density lipoproteins (LDL, d 1.024-1.050 g/ml) was evaluated in 40 normolipidemic male subjects following fractionation by isopycnic density gradient ultracentrifugation into eight major subspecies. The mass profile of our subjects' LDL uniformly displayed single symmetric or asymmetric peaks as a function of density; the peak occurred most...

OBJECTIVES The aim of the study is to compare surrogate markers of cardiovascular disease (CVD) risk, such as adiponectin (APN) levels and low-density lipoprotein (LDL) size, before and after sustained release metformin (Met-SR) therapy in women with polycystic ovarian syndrome (PCOS). METHODS Sixty women with PCOS and sixty age-matched controls in the age group 18-45 years were recruited aft...

BACKGROUND Patients with systemic lupus erythematosus (SLE) are 5-8 times more likely to develop coronary heart disease than the general population. The aim of this study was to find out the prevalence of the small dense low-density lipoprotein (LDL) cholesterol particle in patients with SLE. METHODS We recruited 50 consecutive patients with SLE who had no evidence of hypertension or renal fa...

in this study, a manganite sample with a nominal formula of la0.9sr0.1mno3 was prepared by the microwave assisted sol-gel method and annealing at various temperatures. the structural and magnetic properties of the samples were investigated by xrd, fesem and ac susceptometer, respectively. xrd analysis showed that the samples are a nearly single phase. fesem micrographs showed that by increasing...

in order to ensure the safety of parenterals, international pharmacopoeias and national standards have set up stringent guidelines and standards. particulate con- tamination is a potential health risk caused by intravenous injection of particles large enough to potentially clog the small arteries. particles could be produced through manufacturing and packaging or even dispensing of the pharmace...

Raised serum cholesterol does not adequately explain the increased risk of CHD within populations or the relationship between diet and CHD. Nevertheless, the principal transport vehicle of cholesterol in the circulation, LDL, must still be regarded as the most atherogenic lipoprotein species, but not because of its contribution to serum cholesterol. The atherogenic potential of LDL in the major...