OBJECTIVE Many approaches are being taken to generate cartilage replacement materials. The goal of this study was to use a self-aggregating suspension culture model of chondrocytes with mechanical preconditioning. DESIGN Our model differs from others in that it is based on a scaffold-less, self-aggregating culture model that produces a cartilage tissue analog that has been shown to share many...

Articular cartilage exhibits anisotropic mechanical properties when subjected to tension. However, mechanical anisotropy of mature cartilage in compression is poorly known. In this study, both confined and unconfined compression tests of cylindrical cartilage discs, taken from the adult human patello-femoral groove and cut either perpendicular (normal disc) or parallel (tangential disc) to the ...

Studying the morphology of the thumb carpometacarpal (CMC) joint cartilage in both health and disease is warranted by the high incidence of CMC osteoarthritis (OA), especially in older women; however, quantifying CMC cartilage variation in vivo remains challenging with current modalities. We used a subjectspecific cartilage model that is based on joint space volume computations from sequential ...

Many tissues in the human body consist of cells embedded in an extracellular matrix that has an abundance of charged macromolecules. Examples of such tissues include tendon, bone, cartilage, and corneal stroma. Motions of the body impose on these tissues solid and fluid mechanical stimuli, such as compression, tension, and viscous shear due to fluid flow. Mechanical stimuli may influence cell b...

objective(s): the aim of this study was to synthesis new dental nanocomposites reinforced with fabricated glass nanoparticles and compare two methods for fabrication and investigate the effect of this filler on mechanical properties. materials and methods: the glass nanoparticles were produced by wet milling process. the particle size and shape was achieved using psa and sem. glass nanoparticle...

modern vehicle bodies make intensive use of high strength steel grades to meet the contradicting demand of lighter weight and simultaneously better mechanical performance. for many steel grades microalloying by niobium is the key to achieve their characteristic property profile. in hsla steels niobium enhances the strength primarily by grain refinement. in interstitial free high strength steels...

1. Bovine nasal cartilage was extracted with inorganic salt solutions of various ionic strengths. The efficiency of extraction of protein-polysaccharide from the tissue was determined for each extraction. The results confirm and enlarge earlier observations (Sajdera & Hascall, 1969). 2. The chloride salts of lanthanide metals extract high yields of protein-polysaccharide from the tissue at much...

INTRODUCTION: Slipped capital femoral epiphysis (SCFE) is the most common hip disorder of adolescent children [1]. It results in fracture of the growth cartilage, separating the proximal femoral epiphysis from the metaphysis, due to hormonal and mechanical factors [2]. The most widely accepted treatment for stable SCFE (defined by the ability to bear weight on the affected limb) has been a sing...