Chronic stress is well known to exacerbate pain. We tested the hypothesis that neonatal handling, which induces resilience to the negative impact of stress by increasing the quality and quantity of maternal care, attenuates the mechanical hyperalgesia produced by water-avoidance stress in the adult rat. Neonatal male rats underwent the handling protocol on postnatal days 2-9, weaned at 21 days ...

It is widely accepted that physiological mechanical stimulation suppresses apoptosis and induces synthesis of extracellular matrix by osteoblasts; however, the effect of stress overloading on osteoblasts has not been fully illustrated. In the present study, we investigated the effect of cyclic compressive stress on rat osteoblasts apoptosis, using a novel liquid drop method to generate mechanic...

ATR controls chromosome integrity and chromatin dynamics. We have previously shown that yeast Mec1/ATR promotes chromatin detachment from the nuclear envelope to counteract aberrant topological transitions during DNA replication. Here, we provide evidence that ATR activity at the nuclear envelope responds to mechanical stress. Human ATR associates with the nuclear envelope during S phase and pr...

The chitinase-like protein YKL-40, encoded by the CHI3L1 gene, is a biomarker and functional effector of chronic inflammatory and allergic diseases. In the lung it is associated with asthma severity and reduced lung function. The cellular sources of YKL-40 in human airways and the mechanisms regulating YKL-40 expression are poorly understood. We previously showed that mechanical stress similar ...

We present dynamic tuning and symmetry lowering of Fano resonances in gold heptamers accomplished by applying uniaxial mechanical stress. The flexible heptamer structure was obtained by embedding the seven-gold-nanocylinder complex in a polydimethylsiloxane membrane. Under uniaxial stress, the Fano resonance exhibited opposite spectral shifts for the two orthogonal polarizations parallel and pe...

loading conditions and complex geometry have led the cylinder heads to become the most challenging parts of diesel engines. one of the most important durability problems in diesel engines is due to the cracks valves bridge area. the purpose of this study is a thermo-mechanical analysis of cylinder heads of diesel engines using a two-layer viscoplasticity model. in this article, mechanical prope...

the dissipated energy from periodic deformation is regarded as the main reason for heat generation and temperature rise inside the tire domain. however, the mechanical behavior of rubber parts is highly temperature dependent. in most performed investigations, the influence of thermal effects on stress/ deformation fields of pneumatic tires is ignored and just temperature distribution is conside...

The current study analyzed changes in anterior cruciate ligament (ACL) and lateral collateral ligament stress as a result of mechanical varus. In an exploratory pilot study, progressive mechanical varus was introduced to a male finite element model of the lower limb at different knee flexion angles. Nine situations were analyzed (combinations of 0°, 30°, and 60° knee flexion and 0°, 5°, and 10°...

Background Mechanical stress is a primary determinant of bone growth and remodeling: weight bearing and locomotion stimulate interstitial fluid flow through the bone canalicular system, and the resultant shear stress is a major mechanism whereby mechanical forces stimulate bone growth [1]. In response to fluid shear stress and other types of mechanical stimulation, osteoblasts produce large amo...

This paper studies interfacial mechanical behavior of laminate beams, consisting of two piezoelectric facial sheets and an elastic core. The study is based on coupled multi-filed finite element formulation. The emphasis is placed on mechanical and electric behavior of interfaces between piezoelectric material and elastic material, including effect of geometrical parameters, stress distribution ...