We report a novel approach to study cell migration under physical stresses by utilizing established growth factor chemotaxis. This was achieved by studying cell migration in response to epidermal growth factor (EGF) chemoattraction in a gradually tapered space, imposing mechanical stresses. The device consisted of two 5-mm-diameter chambers connected by ten 600 μm-long and 10 μm-high tapered mi...

Collective cell migration is a highly regulated process involved in wound healing, cancer metastasis, and morphogenesis. Mechanical interactions among cells provide an important regulatory mechanism to coordinate such collective motion. Using a self-propelled Voronoi (SPV) model that links cell mechanics to cell shape and cell motility, we formulate a generalized mechanical inference method to ...

The general principles behind the global mechanical tensioning technique for controlling weld residual stresses are examined using a finite lement model to follow their evolution throughout the welding process. While we focus specifically on friction stir welding, the tool is represented imply as a heat source. As a result, the findings have relevance to a wide range of welding processes. For a...

The objective of this research was to develop and test a procedure for modeling the specimen-specific mechanical response of multicellular constructs to globally applied strains/stresses using the Material Point Method (MPM). Volumetric confocal image data of vascularized collagen constructs were used to generate particle distributions. Refinement and sensitivity studies were performed. A varia...

A network of entangled multiwall carbon nanotubes is an assembly of non-bonded and randomly oriented units whose mechanical behavior is affected by their buckling, compression and slippage at contact points. Slippage and irreversible nanotube rearrangements are evidenced by the hysteresis in the stress-strain curves during loading and unloading cycles. To model the mechanical behavior, a nonlin...