نتایج جستجو برای: mediated feedback

تعداد نتایج: 549367  

Journal: :Science signaling 2011
Liudmilla Rubbi Björn Titz Lauren Brown Erica Galvan Evangelia Komisopoulou Sharon S Chen Tracey Low Martik Tahmasian Brian Skaggs Markus Müschen Matteo Pellegrini Thomas G Graeber

In subtypes and late stages of leukemias driven by the tyrosine kinase fusion protein Bcr-Abl, signaling by the Src family kinases (SFKs) critically contributes to the leukemic phenotype. We performed global tyrosine phosphoprofiling by quantitative mass spectrometry of Bcr-Abl-transformed cells in which the activities of the SFKs were perturbed to build a detailed context-dependent network of ...

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