Three join algorithms are evaluated in an environment with distributed main-memory based mediators and data sources. A streamed ship-out join ships bulks of tuples to a mediator near a data source, followed by post-processing in the client. An extended streamed semi-join in addition builds a main-memory hash index in the client mediator. A ship-in algorithm materializes and joins the data in th...

Many questions in life course epidemiology involve mediation and/or interaction because of the long latency period between exposures and outcomes. In this paper, we explore how mediation analysis (based on counterfactual theory and implemented using conventional regression approaches) links with a structured approach to selecting life course hypotheses. Using theory and simulated data, we show ...

Mediator is a general coactivator complex connecting transcription activators and RNA polymerase II. Recent work has shown that the nuclear receptor-interacting MED1/TRAP220 subunit of Mediator is required for peroxisome proliferator-activated receptor gamma (PPARgamma)-stimulated adipogenesis of mouse embryonic fibroblasts (MEFs). However, the molecular mechanisms remain undefined. Here, we sh...

The Mediator is a multiprotein coactivator required for activation of RNA polymerase II transcription by DNA binding transactivators. We recently identified a mammalian homologue of yeast Mediator subunit Med8 and partially purified a Med8-containing Mediator complex from rat liver nuclei (Brower, C. S., Sato, S., Tomomori-Sato, C., Kamura, T., Pause, A., Stearman, R., Klausner, R. D., Malik, S...

Background: Two CDK subunits of the Mediator complex play pivotal roles in transcription by a mechanism that has not yet been elucidated. Results: The histone arginine methyltransferase PRMT5 is a Mediator CDK-interacting protein. Conclusion: Mediator-associated PRMT5 symmetrically dimethylates histone H4 arginine 3, and this might cause transcriptional repression. Significance: This work enabl...

The object of this study is to analyze the factors influencing success of Bank-issued micropayment systems in Iran. Based on an existing IS post acceptance model which considers well known factors, we focus on studying the influence of a new factor related to compulsion (direct and indirect).  Our model consists of seven main factors along with ‘Direct compulsion’ defined as a mediator v...

Multiple sclerosis (MS) is an inflammatory autoimmune disease which is presented by environmental factors and genetic predisposition, increasingly affecting a large number of people worldwide. CNS inflammation is a local tissue response to stimulants and is characterized by induction of cytokines, chemokines and vascular permeability. Our goal in this study is to understand the micro-environmen...

the purpose of this research, was to determine the impact of contextual variable of change on commitment to change in related to process of privatization through emotional envolvment. in this regard, randomize stratified sampling was selected and 104 managers and specialists of khorasan province regional electric company participated in the study. to collect data was used a questionnaire with 9...

Conflicts of interest occur in various aspects of our daily life and we often come to an understanding by negotiating our way through these conflicts. This paper presents a simple interactive negotiation approach to resolve certain conflicts that involve multiple issues. The focus is on mediation to facilitate a solution based on alternating offers over a finite-time bargaining game. The mediat...