Hereditary hemorrhagic telangectasia (HHT) or Rendu-Osler-Weber syndrome, is a rare genetic disorder with autosomal dominance and variable penetrance. The typical findings of the disease are telangiectasias in skin and mucous membranes, and arteriovenous malformations presenting in the organs like lung, intestine, brain and liver. It is characterized by the classic triad of recurrent epistaxis,...

1 Institute of Patophysiology and Nuclear medicine "Acad Isak S. Tadzer", Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia; 2 University Clinic of Thoraco-Vascular Surgery, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia; 3 Institute of Pathology, Faculty of Medicine, Ss Cyril and Methodius University...

s. Acevska J, Stefkov G, Petkovska R, Kulevanova S, Dimitrovska A. Chemometric approach for development, optimization, and validation of different chromatographic methods for separation of opium alkaloids. Anal Bioanal Chem. 2012 May;403(4):1117-29. Institute of Applied Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy, University Ss. Cyril and Methodius, Skopje, Republic of Macedonia....

Results: The commonest symptoms were epigastric pain, other upper abdominal pain, and dyspepsia while common signs were epigastric and right upper quadrant tenderness, and epigastric mass. Complete data was obtained in 172 patients of which 114 had abnormal findings. The commonest were duodenal ulcer, gastritis and duodenitis. Less common findings were gastric ulcer, gastric cancer and oesophag...

Prodynorphin (PDYN; OMIM: 131340) is the precursor of the dynorphin related peptides which plays an important role in several complex traits such as drug abuse [1]. It has been reported that the expression level of the PDYN gene is significantly increased by cocaine [2]. On the other hand, the Pdyn knockout mice showed increased explorative behavior in anxiety tests suggesting an anxiogenic rol...

Case Report: A 19-year-old male with the diagnosis of syncope, tachycardia with arrhythmia, and chest pain was referred to the University Clinic of Cardiology for the echocardiography. Transthoracic echocardiography showed bicuspid aortic valve with normal left ventricular (LV) dimensions and normal systolic function. Mild thickening of the aortic valve cusps and mild aortic regurgitation was f...

BACKGROUND: The stroke is leading cause of death and severe disability worldwide. Atherosclerosis is responsible for over 30% of all ischemic strokes. It has been recently discovered that plaque morphology may help predict the clinical behavior of carotid atherosclerosis and determine the risk of stroke. The noninvasive imaging techniques have been developed to evaluate the vascular wall in an ...

Diabetic nephropathy (DN) remains the most common cause for end stage renal disease (ESRD) as the burden of diabetes increases worldwide [13]. The mechanisms of DN are not very clear, but the extensive investigation has documented the key role of the rennin angiotensin aldosterone system (RAAS) in the pathogenesis and pathophysiology of DN [4]. Accordingly, blockade of the RAAS is first-line th...