The results of recent clinical trials of medicinal cannabinoid drugs show that dizziness and vertigo are commonly reported adverse side-effects. Cannabinoid CB1 receptors were initially thought to be expressed in very low densities in the vestibular nucleus complex (VNC). Recent immunohistochemical studies have challenged this idea and suggested that CB1 receptors may exist in numbers similar t...

Due to severe toxicity of pyrrolizidine alkaloids, their quantification in medicinal products is very important. The idea of this research was to use retrorsine as a surrogate reference compound instead of lycopsamine reference or lycopsamine isolated from comfrey. A method for the analysis of lycopsamine in extracts of comfrey roots was developed and validated, employing thin layer chromatogra...

The usage amount of medicinal plant rapidly increased along with the development of traditional Chinese medicine industry. The higher market demand and the shortage of wild herbal resources enforce us to carry out large-scale introduction and cultivation. Herbal cultivation can ease current contradiction between medicinal resources supply and demand while they bring new problems such as pestici...

since there is limited information on the simultaneous effect of drought stress and salicylic acid on yield and mucilagecontent of the medicinal herb, plantago ovata forssk is available, a pot experiment was conducted in factorial form basedon a randomized complete block design with three replications in jiroft, kerman province, south of iran. as the firstfactor, drought stress included four le...

Status Last revised 1990 Previous titles/other references Clinical Testing of Sustained Release Forms intended to ensure Prolonged Action/ III/1968/87 Additional Notes This note for guidance concerns the application of Part 4, section C of the Annex to Directive 75/318/EEC as amended with a view to the granting of a marketing authorisation for a medicinal product. It is mainly devoted to extend...

In herbal medicinal products the entire herbal drug or an herbal drug preparation is regarded as the active pharmaceutical ingredient, regardless of whether constituents with defined therapeutic activity are known. In quality control and stability testing of herbal medicinal products, fingerprint chromatograms are used as powerful tools to evaluate and compare the composition of compounds in su...

In the previous years the synthesis of high nitrogen containing heterocyclic systems has been attracted to many pharmaceutical and agrochemical industries. The triazole nucleus is one of the most important heterocycles which is a feature of natural products and medicinal agents. Triazole nucleus is enjoying their importance as being the center of activity. The nitrogen containing heterocyclics ...

According to Ayurveda there are large numbers of traditional medicinal uses of Ziziphus species and the reasons behind the medicinal potential of this plant are because of some allied substances such as ascorbic acid, thiamine, riboflavin and bioflavonoids and pectin-A. Therefore, this plant is a valuable source of phytochemicals, bioactives, vitamins etc. which makes it to be effective in curi...

Mushrooms possess nutritional and medicinal properties that have long been used for human health preservation and that have been considered by researchers as possible sources of free radical scavengers. In this work, the antioxidant properties of water extracts from Agaricus blazei Murill, produced by maceration and decoction, are demonstrated in vitro. Resistance to oxidation is demonstrated t...

In the present study, changes of total phenolic concentration and radical-scavenging activity were evaluated in the shoots of Artemisia aucheri -a medicinal plantthat had been exposed as seeds to magnetic fields (90 or 200 mT for 5 and 20 min) and that were irrigated for one month with NaCl (150 mM) under glasshouse conditions. Total phenolic content and radical-scavenging activity decreased in...