By B. J. KOSZEW’SKI, M.D. H YPERCHROMIC megaloblastic anemia is not a disease entity. Besides the pernicious anemia of Addison-Biermer w’hich is due to a lack of Castie’s intrinsic principle in the gastric juice, there is a series of illnesses that cat lead to the deficiency of the atltianemic principle atld subsequently typical hematologic changes. According to Castle and Mitlot.,’3 Rohr,5#{17...

The absorption of (60)CoB(12) has been studied in a group of patients suffering from megaloblastic anaemia associated with pregnancy and in a control group. The mean urinary excretion of (60)CoB(12) in the patients with megaloblastic anaemia is not significantly different from that of the control group. Five of the 30 patients showed a value towards the lower limit of normal, but the serum vita...

A 71-year-old man with diabetes mellitus visited our hospital with complaints of anorexia and weight loss (12 kg/3 months). He had megaloblastic anemia, cobalamin level was low, and autoantibody to intrinsic factor was positive. He was treated with intramuscular cyanocobalamin, and he was able to consume meals. GAD autoantibody and ICA were positive, and he was diagnosed with slowly progressive...

S OF SPECIAL INTEREST STUDIES OF CELIAC DISEASE. I. THE APPARENT IDENTICAL AND SPECIFIC NATURE OF THE DuoDENAL AND PROXIMAL JEJUNAL LESION IN CuilAc DISEASE AND IDIOPATHIC SPRUE. Cyrus E. Rubin, Lloyd L. Brandborg, Patricia C. Phelps and Hawley C. Taylor, Jr. From the Department of Medicine, University of Washington, Seattle, Washington. Gastroenterology 38:28, 1960. Histologically, the duodena...

5. Udenfriend, S., Fluorescence Assay in Biology and Medicine. Academic Press,New York, N. Y., 1969, pp 304-306 and 324-337. 6. Liebermen, F. L., and Bateman, J. R., Megaloblastic anemia possibly induced by triamterene in patients with alcoholic cirrhosis: 2 case reports. Ann. Intern. Med. 68, 168 (1968). 7. Pupita, F., Bert, G., Mathis, I., and Rappelli, A., Assorbimento ed eliminazione del tr...

Aim: Deficiency of cobalamin and folate during pregnancy is associated with megaloblastic anemia. Lower levels of folate and vitamin B12 were reported in mothers whose offspring had neural tube defects compared to unaffected controls. Increased methylmalonic acid (MMA) levels are a sensitive indicator of mild vitamin B12 deficiency and elevated homocysteine levels denote vitamin B12 or folate d...