According to the results obtained after immunologic, hormonal and biochemical status investigations has been discussed peculiarities of melanogenesis in 135 patients with skin hyper pigmentation (78 patients with pigmented nevus and 57 – with melasma). The average age consisted – 36,5 year. Of 135 patients 32 were men and 103 women. Patients with pigmented nevus revealed increased rate of CD4, ...

To evaluate the efficacy of a functional microarray of microneedles (MNs) plus topical tranexamic acid (TA) for melasma in middle-aged women in China.Thirty female subjects with melasma were enrolled in this study. The left or right side of the face was chosen randomly to be pretreated with a functional microarray of MNs, followed by topical 0.5% TA solution once per week for 12 weeks. The othe...

Chloasma is a required hypermelanosis of sun-exposed areas occurred during pregnancy and it can affect 50-70% of pregnant women. It presents as symmetric hyperpigmented macules, which can confluent or punctuate. The most common locations are the cheeks, the upper lip, the chin and the forehead. The exact mechanism by which pregnancy affects the process of melanogenesis is unknown. Estrogen, pro...

M elasma is a relatively common, but underdiagnosed, skin condition that can be a challenge to treat for primary care physicians. Our case involves a 39-year-old G3P2A1 Hispanic female not on any hormonal manipulation for birth control and no significant past medical history who presented with a facial rash of 4 years’ duration which had not been relieved by moisturizer and over-the-counter ste...

Background. Cucumber is one of the natural ingredients that has been widely used traditionally to maintain facial skin health. rich in antioxidants which have potential suppress inflammatory process arises due hormonal imbalances melasma sufferers use injectable contraception. This study aimed determine effect using a cucumber mask on incidence acceptors injection contraception users at indepen...

O presente trabalho trata sobre o Melasma na gravidez e visa falar suas causas seu tratamento. Assim, objetivo do é discorrer acerca dos principais fatores de prevenção tratamentos existentes para gravidez. Para tanto, os objetivos secundários consistem em conceituar Melasma, apresentar as surgimento seus desenvolvimento relacionar com a método utilizado metodologia revisão bibliográfica pesqui...

Melasma is a challenging chronic skin condition associated with hyperpigmentation and unknown aetiology. This scoping review maps evidence of available treatments their effectiveness in darker types. A comprehensive, systematic online search was conducted Scopus, PubMed, CINAHL Complete, Cochrane, ScienceDirect, Web Science Core Collection. All eligible titles were exported to an EndNote20 libr...

Melasma is a fairly common condition that the result of hyperpigmentation caused by increased melanin secretion. In course melasma, certain areas skin become darker than rest epidermis. Although pathogenesis remains incompletely clarified, several contributing factors have been identified, namely exposure to ultraviolet and visible light, family predisposition, pregnancy, use exogenous hormones...

Abstract Oral tranexamic acid (TXA) demonstrates promising results in melasma treatment; however, TXA dosing management has been a cause for persistent speculation. There is still no consensus to guide dosing, duration of therapy and need maintenance treatment. Our aim was evaluate compare the efficacy two different regimens, 250 mg twice daily vs. 500 patients with using modified Melasma Area ...

This article reviews an old drug tranexamic acid to its new use in the treatment of melasma. Its mechanism of preventing the activation of melanocyte from UV light, hormone and injured kerationcyte through the inhibition of the plasminogen activator system will be explored. The detail usage for such indication and its safety profile will also be thoroughly evaluated.