Hypocomplementemic urticarial vasculitis (HUV) is the rare immune complex vasculitis, affecting small vessels and associated with anti-C1q antibodies, presenting with urticaria and hypocomplementemia. Glomerulonephritis, arthritis, obstructive pulmonary disease, and ocular inflammation are common in HUV. HUV may present as an idiopathic disease or be a part of systemic autoimmune or autoinflamm...

Lyme borreliosis is a chronic illness caused by tick-transmitted spirochete Borrelia burgdorferi. Borreliosis can be extremely threatening if it is not diagnosed and treated in early stages. Kidneys are not typically involved in the disease. However, in infected dogs, Lyme nephritis is present in 5-10% of cases. It is associated with rapidly progressing renal failure. Histopathological examinat...

PURPOSE A synthetic adrenocorticotropin (ACTH) analog has shown efficacy in Europe as primary and secondary therapy for nephrotic syndrome, but there is no published experience using the natural, highly purified ACTH gel formulation, available in the United States, for nephrotic syndrome. We therefore investigated the use of ACTH gel for nephrotic syndrome in the United States. PATIENTS AND M...

BACKGROUND The concomitant occurrence of a vasculitic glomerulonephritis and membranous nephropathy in the same patient is unusual. We report data on 10 patients with this unusual combination. METHODS Ten patients (nine males/one female; median age 63.5 years, range 30-70 years) presented between 1981 and 1995 with: acute renal failure (n = 3), nephrotic syndrome (n = 4), non-nephrotic range ...

Utilizing the fluorescent antibody method for the histologic demonstration of localized gamma-globulins, we have made the following observations (in contradistinction to the lack of such findings in a variety of normal and pathologic, control kidneys). In systemic lupus erythematosus (a) gamma-globulins were localized in the thickened capillary walls, the "wire-loop" lesions, and the so called ...

A number of experimental immunologic models of glomerulonephritis have been devised in animals in order to better understand mechanisms of immune glomerular injury. From these studies two general pathogenic categories have been defined (1). The first, immune complex injury, involves the interaction of circulating host or foreign antigen with antibody resulting in the formation of soluble comple...

Kt/V 1.5 (0.40) 1.3 (0.28) 0.28 Age 66.2 (12.7) 66.5 (13.9) 0.48 Male [n (%)] 5 (50.0) 8 (72.7) 0.39 Female [n (%)] 5 (50.0) 3 (27.3) Time on haemodialysis in months 40.6 (30.5) 38.7 (50.1) 0.92 Current use of 1-OH-vitamin D 0.5 (0.5) 0.7 (0.5) 0.31 Current use of cinacalcet 0.3 (0.5) 0.5 (0.5) 0.28 PTH (ng/L) 317.5 (334.0) 525.8 (474.3) 0.26 Fetuin A (g/L) 0.4 (0.1) 0.4 (0.1) 0.53 Corrected ca...

Kt/V 1.5 (0.40) 1.3 (0.28) 0.28 Age 66.2 (12.7) 66.5 (13.9) 0.48 Male [n (%)] 5 (50.0) 8 (72.7) 0.39 Female [n (%)] 5 (50.0) 3 (27.3) Time on haemodialysis in months 40.6 (30.5) 38.7 (50.1) 0.92 Current use of 1-OH-vitamin D 0.5 (0.5) 0.7 (0.5) 0.31 Current use of cinacalcet 0.3 (0.5) 0.5 (0.5) 0.28 PTH (ng/L) 317.5 (334.0) 525.8 (474.3) 0.26 Fetuin A (g/L) 0.4 (0.1) 0.4 (0.1) 0.53 Corrected ca...